PerkinElmer

Results for 'TRF1343'

Business Insights (1)
Filters:

Sort by

1-1 of 1 Business Insights

  • Application Note

    Measuring PD-L1 and PD-1 Expression in Human Cells with LANCE Ultra TR-FRET

    Immuno-oncology is an exciting area within cancer research and among the most promising approaches to activating therapeutic antitumor immunity is through the blockade of immune checkpoints. The programmed cell death-1 (PD-1) immune checkpoint pathway is a negative regulator of T cell immune function. When PD-1 is bound to programmed cell death-ligand 1 (PD-L1), T cell response is suppressed. Many tumor cells escape anti-tumor immunity through their expression of Programmed Death Ligand 1 (PD-L1 or B7-H1), which interacts with T cell-expressed PD-1 and results in T cell apoptosis. PD-L1 expression has been studied in multiple different cancers. While several anti-PD-1 or PD-L1 monoclonal antibodies that block the PD-1/ PD-L1 complex formation have been developed to date, there remains a need for more robust, rapid, high-throughput assays to identify and qualify novel inhibitors of PD-1/PD-L1 binding and assays to detect expression levels of both binding partners. Find out how LANCE® Ultra Technology provides a fast, powerful, homogeneous platform for identifying and characterizing endogenous PD-L1 and PD-1 expression in human cells.

Products & Services (2)
Filters:

Sort by

1-2 of 2 Products & Services

  • Protein

    PD-1 (human), lyophilized (LANCE)

    Human PD-1 standard, for use in running standard curves in LANCE Ultra TR-FRET assays. This standard is already provided in the LANCE Ultra Human PD-1 TR-FRET Detection Kit, but can also be ordered separately.
    List Price : 321.00 USD
  • LANCE Detection Kit

    PD-1 (human) LANCE Ultra TR-FRET Detection Kit

    The LANCE® Ultra Human PD-1 Detection Kit is designed for detection and quantitation of human PD-1 in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
    Price Range : 840.00 USD - 11200.00 USD