PerkinElmer
check quantity

WIN 35428, [N-Methyl-3H]-, 25 µCi (37 MBq)

WIN 35428 [(–)-2-β-Carbomethoxy-3-β-(4-fluorophenyl)tropane], tritiated on the N-methyl group. WIN 35428 acts as an antagonist at dopamine transporters (DATs).

Please enter valid quantity

Please login to add favorites

NULL OR EMPTY CART

Part Number Unit Size List Price Your Price Quantity
NET1033025UC 25 µCi 705.00 USD
NET1033250UC 250 µCi 2333.00 USD
NET1033001MC 1 mCi 5100.00 USD
Buy Now

You successfully added item(s) to your cart

Overview

WIN 35428 is a dopamine reuptake inhibitor, and is a stimulant drug. These transporters are potential drug targets for attention deficit hyperactivity disorder (ADHD), bipolar disorder, clinical depression, and alcohol addiction.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1033:

  1. Hong, W.C., Yano, H., Hiranita, T., Chin, F.T., McCurdy, C.R., Su, T., Amara, S.G., Katz, J.L., The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats. Journal Biological Chemistry, 2017, 292 (27): 11250-11261.
  2. Hong, W.C., and Amara, S.G., Membrane Cholesterol Modulates the Outward Facing Conformation of the Dopamine Transporter and Alters Cocaine Binding. Journal of Biological Chemistry, 2010, 285 (42): 32616-32626.

Specifications

Concentration 1.0 - 10 mCi/mL
Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 277.3
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Dopamine
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 25 µCi