Tumor neo-vasculature, characterized by the development of abnormal, leaky and tortuous blood vessels, represents a key target for cancer imaging and therapy. Among the various recognized tools for measuring microvessel density is tomato (Lycopersicon esculentum) lectin, a single polypeptide glycoprotein that binds to sugar-containing proteins present on the endothelium.
TLectinSense™ 680 is a fluorescent in vivo endothelial cell imaging agent. TLectinSense 680 fluorescent agent is a near-infrared labeled macromolecule that targets the vasculature and enables imaging of blood vessels and angiogenesis. This agent in conjunction with PerkinElmer’s imaging instruments helps in assessing vascularity in vivo and in real time, without termination of mice, excision and processing of the tissue, thus improving the efficacy, early detection and monitoring of anti-angiogenic therapies.
Disclaimer: For laboratory use only. This product is intended for animal research only and not for use in humans.
|Fluorescent Agent Type||Targeted|
|Optical Imaging Classification||Fluorescence Imaging|
|Product Brand Name||TLectinSense|
|Quantity in a Package Amount||1.0 Units|
|Shipping Condition||Blue Ice|
|Therapeutic Area||Angiogenesis, Oncology/Cancer|
|Unit Size||1 Vial (10 doses)|
|Wave Length||680 nm|
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|Resource Type||File Name||File Format|
|Brochure||In Vivo Imaging Agents Brochure||PDF 2 MB|
|Brochure||TLectinSense™ 680 (Product Sheet)||PDF 1 MB|
|Technical Note||TLectinSense™ 680 (Data Sheet)||PDF 311 KB|
|Technical Note||TlectinSense 680 (Protocol)||PDF 257 KB|
|Poster||Targeted in vivo imaging of tumor vasculature using a near infra-red labeled tomato lectin agent||PDF 1007 KB|
|Citations Library||View peer reviewed publications using PerkinElmer's In Vivo Imaging Reagents||Link|
|Webinars||View our complete list of in vivo webinars available on demand||Link|