PerkinElmer
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Superhance 680 Fluorescent Imaging Agent

Near-infrared (NIR) fluorescent agent for in vivo imaging and other applications. 

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For laboratory use only. This product is intended for animal research only and not for use in humans.

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NEV10116
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Detail Information

Superhance™ 680 is a small molecule fluorescent in vivo blood pool imaging agent. Superhance 680 fluorescent imaging agent enables imaging of circulation, blood vessels, vasculature, vascular leak, including that associated with early oncologic and opthalmologic lesions. This agent binds to albumin in blood for extended (30m-1h) circulation.

Specifications

Fluorescent Agent Type Vascular
Optical Imaging Classification Fluorescence Imaging
Product Brand Name Superhance
Quantity in a Package Amount 1.0 Units
Shipping Condition Ambient
Therapeutic Area Vascular disease, Angiogenesis, Inflammation, Oncology/Cancer
Unit Size 1 Vial (10 doses)
Wave Length 680 nm
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Application Note

Vascular Imaging Probes For Oncology and Inflammation Using the IVIS Spectrum

Optical-based in vivo imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. A number of fluorescent imaging probes that circulate with the blood, but have no target selectivity, have been used to detect tumor leakiness as an indication of abnormal tumor vasculature. Inflammation is also characterized by distinct vascular changes, including vasodilation and increased vascular permeability, which are induced by the actions of various inflammatory mediators. This process is essential for facilitating access for appropriate cells, cytokines, and other factors to tissue sites in need of healing or protection from infection. This application note investigates the use of three fluorescent imaging probes, to detect and monitor vascular leak and inflammation in preclinical mouse breast cancer models.

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Technical Note

Superhance 680 (Data Sheet)

Superhance 680 is a small molecule fluorescent in vivo blood pool imaging agent. Superhance 680 enables imaging of circulation, blood vessels, vasculature, vascular leak, including that associated with early oncologic and opthalmologic lesions.

PDF 51 KB