| Inner Diameter | 4.6 mm |
|---|---|
| Length | 100.0 mm |
| Particle Size | 1.7 µm |
| Product Brand Name | Quasar |
| Type | C8 |
Fluoxetine hydrochloride is an antidepressant belonging to a class of drugs known as selective serotonin reuptake inhibitors. It was notably marketed as Prozac. Fluoxetine is also effective at treating obsessive compulsive disorder and bulimia. It blocks the serotonin reuptake transporter in the presynaptic terminal which results in increased levels of serotonin in certain areas of the brain. Fluoxetine is favorable in comparison with older antidepressants as it is a selective inhibitor for serotonin, has weak affinity for noradrenaline receptors and no affinity for dopamine receptors, giving it a far more desirable adverse effect profile. This application brief describes the use of a Quasar™ C8 column for the analysis of fluoxetine hydrochloride in accordance with the official Fluoxetine Hydrochloride USP monograph.
Lopinavir and ritonavir are commonly prescribed as a fixed-dose combination drug therapy for the treatment of Human Immunodeficiency Viruses (HIV) and belong to a class of antiviral drugs known as protease inhibitors. Lopinavir by itself has insufficient bioavailability to be an effective therapy. However, ritonavir inhibits cytochrome P450 enzymes in the liver known to break down lopinavir, increasing its concentration in the blood to its desired therapeutic window. Lopinavir and ritonavir treatment as a single medication is listed by the World Health Organization’s (WHO) list of essential medicines, which serves as a model of the safest and most effective medicines required by a health system. Early studies have shown promising results as a treatment against SARS-CoV-2 and further research is currently being conducted into its efficacy. This application brief describes the use of a Quasar C8 column for the analysis of lopinavir and ritonavir.
Omeprazole belongs to a class of drugs known as Proton Pump Inhibitors (PPI’s). It is used in the treatment of conditions relating to overactive stomach acid such as gastroesophageal reflux disease, peptic ulcers and Zollinger-Ellison syndrome. The World Health Organization regards omeprazole among its ‘List of Essential Medicines’ which outlines the most effective and safest medicines required by a countries healthcare system to meet its needs. Omeprazole is a very commercially important drug, being ranked as the 7th most prescribed drug in the USA in 2017 with over 58 million prescriptions. This application brief describes the use of a Quasar C8 column for the analysis of omeprazole in accordance with the United States Pharmacopoeia (USP) monograph.
Paracetamol, also known as acetaminophen, is an analgesic/antipyretic drug, that reduces fever and pain and is ubiquitous in treating these symptoms. Providing relief for these common symptoms combined with the fact that paracetamol is very well tolerated (in comparison with other analgesics such as aspirin) go towards explaining why it is so widely used. Paracetamol has generic status with many manufacturers making it a commercially important compound. Despite being so widely used the mechanism of action of paracetamol is not fully known. It has been shown to interact with same enzymes as non-steroidal anti-inflammatory drugs, but exclusively in the central nervous system as oppose to the periphery. This application brief describes the use of a Quasar C8 for the analysis of paracetamol adapted from the official USP monograph.
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