Quasar™ C18 LC columns, based on ultra high purity silica and manufactured to tight specification, provides high efficiency separations and excellent peak shape for a wide range of compounds. Our methodology to yield high surface coverage enhances the pH stability and extends the working range. If data integrity and high productivity are top priorities for your lab, then this column can support your needs for any application.
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|Inner Diameter||4.6 mm|
|Particle Size||5.0 µm|
|Product Brand Name||Quasar|
Azithromycin, discovered in 1980, is a semi-synthetic macrolide antibiotic derived from erythromycin. The drug is primarily used to treat various bacterial infections including respiratory infections, acute bacterial sinusitis, skin infections, Lyme disease, and some sexually transmitted infections. The mode of action of azithromycin is by inhibiting bacterial protein synthesis through binding to the 50S subunit of the bacterial ribosome, thereby inhibiting translation of mRNA. The USP monograph for the analysis of azithromycin states the use of a high pH mobile phase (pH 11), which requires a specific and expensive column. The method also uses amperometric electrochemical detection, which is often unavailable in many laboratories. HPLC with a UV or PDA detector provides a good alternative as it is available in most laboratories. This application brief describes the use of a Quasar™ C18 column in the analysis of azithromycin.
Metformin belongs to a class of drugs known as biguanides and contains the active ingredient metformin hydrochloride. Metformin oral tablets are used, in combination with diet and exercise, to treat high blood glucose levels in patients with type 2 diabetes mellitus. Tablets are often used as monotherapy, or in combination with other anti-diabetic agents or insulin.
This application brief describes the use of a Quasar C18 column for the analysis of metformin hydrochloride RS in accordance with Dissolution Test 3 in the United States Pharmacopoeia (USP) monograph for metformin hydrochloride tablets.