ProSense® 750 FAST is part of a family of activatable fluorescent imaging agents comprising a novel architecture termed F.A.S.T. (Fluorescent Activatable Sensor Technology) that confers an improved pharmacokinetic profile with earlier imaging time points. This architecture offers higher target specific signal with reduced background while also reducing the optimal imaging time after injection.
ProSense 750 FAST is a protease-activatable, pan-cathepsin fluorescent in vivo imaging agent that is activated by key disease associated proteases such as Cathepsin B, L, S, K, V and D. ProSense 750 FAST is not cleaved by trypsin or plasmin.
Cathepsins are produced by inflammatory and tumor cells. ProSense 750 FAST is optically silent in its un-activated state and becomes highly fluorescent following protease-mediated activation. ProSense 750 FAST has a half-life in plasma of 30 minutes. ProSense 750 FAST may be used to study disease onset and progression in animal models of oncology, inflammation and atherosclerosis.
Disclaimer: For laboratory use only. This product is intended for animal research only and not for use in humans.
|Fluorescent Agent Type||Activatable|
|Optical Imaging Classification||Fluorescence Imaging|
|Product Brand Name||ProSense|
|Quantity in a Package Amount||1.0 Units|
|Shipping Condition||Blue Ice|
|Unit Size||1 Vial (10 doses)|
|Wave Length||750 nm|
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|Resource Type||File Name||File Format|
|Brochure||FMT Fluorescence Tomography in vivo Imaging Systems||PDF 1 MB|
|Brochure||In Vivo Imaging Agents Brochure||PDF 2 MB|
|Application Note||In Vivo Imaging of Atherosclerosis Disease Using FMT||PDF 1 MB|
|Application Note||Noninvasive In Vivo Quantitation of Asthma Severity Using FMT||PDF 488 KB|
|Technical Note||ProSense 750 FAST (Protocol)||PDF 258 KB|
|Technical Note||ProSense® 750 FAST (Data Sheet)||PDF 164 KB|
|Poster||Non-Invasive Quantitative Tomography of Disease Progression and Therapeutic Response||PDF 581 KB|
|Citations Library||View peer reviewed publications using PerkinElmer's In Vivo Imaging Reagents||Link|
|Webinars||View our complete list of in vivo webinars available on demand||Link|