PerkinElmer
check quantity

Prazosin, [7-Methoxy-3H]-, 1mCi (37MBq)

Prazosin, tritiated at the 7-methoxy position. Prazosin acts as an inverse agonist at the α1-adrenergic receptor.

Please enter valid quantity

Please login to add favorites

NULL OR EMPTY CART

Part Number Unit Size List Price Your Price Quantity
NET823025UC 25 µCi 698.00 USD
NET823250UC 250 µCi 2316.00 USD
NET823001MC 1 mCi 5500.00 USD
Buy Now

You successfully added item(s) to your cart

Overview

Prazosin is an α1-blocker, and is used to treat high blood pressure, anxiety, and post-traumatic stress disorder. It binds the α1-adrenergic receptor, a GPCR that plays a role in vasconstriction and appetite suppression.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET823:

  1. Oshita, M., Kigoshi, S. and Muramatsu, I. (1991), Three distinct binding sites for [3H]-prazosin in the rat cerebral cortex. British Journal of Pharmacology, 104: 961–965.
  2. Hanft, G., Gross, G., Beckeringh, J. J. and Korstanje, C. (1989), α1-Adrenoceptors: the ability of various agonists and antagonists to discriminate between two distinct [3H]prazosin binding sites. Journal of Pharmacy and Pharmacology, 41: 714–716.

Specifications

Concentration 1.0 - 10 mCi/mL
Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 382.4
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Adrenoceptors
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Cardiovascular, Metabolic Disorders
Unit Size 1 mCi