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Pancreatic Polypeptide (human), [125I], 10µCi

Human pancreatic polypeptide (PP), labeled with 125I. Pancreatic polypeptide acts as an agonist at Pancreatic polypeptide receptors (Neuropeptide Y receptors), a class of GPCRs involved in appetite, circadian rhythm, and anxiety.

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NEX315010UC
10 µCi
1011.00 USD
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NEX315050UC
50 µCi
2288.00 USD
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Detail Information

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX315:

  1. Sejling, AS., Lange, K.H.W., Frandsen, C.S. et al. (2015), Infrared thermographic assessment of changes in skin temperature during hypoglycaemia in patients with type 1 diabetes, Diabetologia 58: 1898-1906.
  2. Dirksen, C., Jørgensen, N.B., Bojsen-Møller, K.N., Kielgast, U., Jacobsen, S.H., Clausen, T.R., Worm, D., Hartmann, B., Rehfeld, J.F., Damgaard, M., Madsen, J.L., Madsbad, S., Holst, J.J., Hansen, D.L. (2013), Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass. Int J Obes, 37 (11): 1452-1459.

Specifications

Detection Method Radiometric
Fresh Lot Days Fourth Monday of each month
Label Position Nominally Labeled
Molecular Weight 4179.0
Product Brand Name NEN Radiolabeled Ligands
Radioisotope I-125
Radionuclide 125I
Receptor Type Neuropeptide Y
Shipping Condition Ambient
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Metabolic Disorders, Gastrointestinal
Unit Size 10 µCi
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Using the NENSure Packaging System from PerkinElmer

Since 1985, the unique NENSure system has set the standard for radiochemical packaging. Based on proven performance over millions of shipments, the system provides: Ease of use, Safe storage of unused product and Reduced radiation exposure. Many NEN brand research products, including 32P-, 33P-, 35S-, 3H-, 14C- and 125I-labeled compounds, are packaged in the NENSure System, as are most radionuclides.

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