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Opal 7 Tumor Infiltrating Lymphocyte Kit

The Opal Tumor Infiltrating Lymphocyte Kit enables phenotyping of T cells, B cells and cancer cells within intact FFPE tissue sections.

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OP7TL1001KT 3492.00 USD
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Overview

The Opal 7 Tumor Infiltrating Lymphocyte Kit enables phenotyping of T cells, B cells and cancer cells within intact formalin-fixed, paraffin-embedded tissue sections.

The kit includes all critical workflow reagents to enable 6-plex fluorescent immunohistochemistry: primary antibodies, antibody diluent, fluorescent IHC detection reagents, Spectral DAPI, and antigen retrieval buffers. This kit was configured and validated for multispectral imaging on the Vectra and Mantra Systems. Contains enough reagents for 6-plex immunostain of 50 slides.

  • Optimized panel for assessment of TILs in intact FFPE tissue
  • Shortest path to results
  • Part of the Phenoptics workflow for immunophenotyping of solid tumors

Disclaimer:  For research use only. Not for use in diagnostic procedures.

Specifications

Assay Target CD4,CD8,CD20,FOXP3,CD45RO,panCK
Automation Compatible No
Detection Method MSI, Fluorescence
Fluorophore Opal 520,Opal 540,Opal 570,Opal 620,Opal 650,Opal 690
Product Brand Name Opal
Quantity in a Package Amount 1.0 per pack
Target Species Human
Unit Size 50 slides

Tools

Resources, Events & More

All (22)
Resource Type File Name File Format
Brochure Brochure: Phenoptics Portfolio PDF  2 MB
Data Sheet Data Sheet: Opal 7 Tumor Infiltrating Lymphocyte Panel Kit TDS PDF  255 KB
Flyer Flyer: Phenotype and Visualize with Opal Kits PDF  3 MB
Product Info Product Info: Let's Rid the World of Ribbons - Infographic PDF  822 KB
Opal Multiplex IHC Assay Development Guide Guide: Opal Multiplex IHC Assay Development Guide
Phenoptics Research Solutions e-book Phenoptics Research Solutions E-Book E-book
Scientific Paper Publication: Linch, Stefanie N., et al. "Combination OX40 agonism/CTLA-4 blockade with HER2 vaccination reverses T-cell anergy and promotes survival in tumor-bearing mice." Proceedings of the National Academy of Sciences 113.3 (2016): E319-E327 Link
Scientific Paper Publication: Miecnik, Bernhard, et al. "The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis." Science translational medicine 8.327 (2016) Link
Scientific Paper Publication: Esbona, Karla, et al. "COX-2 modulates mammary tumor progression in response to collagen density." Breast Cancer Research 18.1 (2016) Link
Scientific Paper Publication: Feng, Zipei, et al. "Multispectral Imaging of T and B Cells in Murine Spleen and Tumor." The Journal of Immunology 196.9 (2016): 3943-3950 Link
Scientific Paper Publication: NEJM: Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma Link
Scientific Paper Publication: Novartis Genoptix Shows Multiplexed IHC Test Better Predicts Immunotherapy Response Link
Scientific Paper Publication: Woods, Katherine, et al. "Mismatch in epitope specificities between IFNγ inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma." Journal for immunotherapy of cancer 4.1 (2016) Link
Scientific Paper Publication: Huang, Fangjin, et al. "Quantitative imaging for development of companion diagnostics to drugs targeting HGF/MET." The Journal of Pathology: Clinical Research (2016) Link
Scientific Paper Publication: NEJM: PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma Link
Scientific Paper Publication: Ören, Bilge, et al. "Tumour stroma-derived lipocalin-2 promotes breast cancer metastasis." The Journal of Pathology (2016) Link
Scientific Poster Poster: Optimization Strategy For Fluorescence Multiplex Immunohistochemistry Tissue Staining Link
Scientific Poster Poster: Automate Your Complete Cancer Research Workflow with Phenoptics™ Link
Support Pages Application Support Knowledgebase: Opal Multiplex IHC Assay FAQs Link
Webinars Webcast: The Beginning of the End - Immunoprofiling Coming of Age Link
Webinars Webinar: Untangling the tumor microenvironment: Illuminating the complex interactions and functions of immune cells Link
Webinars Webinar: Using multiplexed IHC to Effectively Navigate the Hidden Clues of the Immunological Microenvironment Link