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MMPSense 680 Fluorescent Imaging Agent

Matrix metalloproteinases (MMPs) are calcium-dependent zinc containing endopeptidases responsible for the degradation of most of extracellular matrix proteins during organogenesis, growth and normal tissue turnover. MMPs play a role in almost every biological cell process from embryo implantation to cell death and have been implicated in a wide range of diseases including inflammation, arthritis, pulmonary disease, cancer and more.

PerkinElmer’s MMPSense NIR activatable fluorescence agents are designed to evaluate many disease related processes including cancer progression, rheumatoid arthritis, pulmonary disease and more as well as evaluating therapeutic efficacy of potential drug candidates.

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For laboratory use only. This product is intended for animal research only and not for use in humans.

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MMPSense 680 Fluorescent Imaging Agent
731.00 USD
MMPSense 645 FAST Fluorescent Imaging Agent
731.00 USD
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Detail Information

MMPSense 680 is excited by 680 + 10 nm excitation light, and emits at 700 + 10 nm. MMPSense 680 has an optimal imaging window of 24-36 hours after injection, allowing workflow flexibility in acquiring data in large animal cohorts. Including MMPSense 680 in careful experimental design allows for multiplexing with other channels and/or imaging times, and so can be paired with other probes to achieve maximum efficiency and flexibility in imaging.


Fluorescent Agent Type Activatable
Optical Imaging Classification Fluorescence Imaging
Product Brand Name MMPSense
Quantity in a Package Amount 1.0 Units
Shipping Condition Blue Ice
Therapeutic Area Atherosclerosis, Arthritis, Inflammation, Oncology/Cancer
Unit Size 1 Vial (10 doses)
Wave Length 680 nm
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Application Note

Multiplex 2D Imaging of NIR Molecular Imaging Agents on the IVIS SpectrumCT and FMT 4000

Epifluorescence (2D) imaging of superficially implanted mouse tumor xenograft models offers a fast and simple method for assessing tumor progression or response to therapy. This approach for tumor assessment requires the use of near infrared (NIR) imaging agents specific for different aspects of tumor biology, and this Application Note highlights the ease and utility of multiplex NIR fluorescence imaging to characterize the complex biology within tumors growing in a living mouse.


Data Sheet

MMPSense 680 (Data Sheet)

MMPSense 680 is a protease activatable fluorescent in vivo imaging agent that is activated by key matrix metalloproteinases (MMPs) including MMP-2, -3, -9 and -13.

MMPSense 680 (Protocol)

MMPSense 680 Activatable Fluorescent Imaging Agent

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