PerkinElmer
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MMP-10 (human) LANCE Ultra TR-FRET Detection Kit, 10,000 assay points

The LANCE® Ultra Human MMP-10 Detection Kit is designed for detection and quantitation of human MMP-10 in cell culture media and cell supernatants using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.

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For research use only. Not for use in diagnostic procedures.

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Unit Size
List Price
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TRF3000C
500 Assay Points
2405.00 USD
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TRF3000M
10,000 Assay Points
11100.00 USD
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Detail Information

The LANCE Ultra Human MMP-10 Detection Kit is designed for detection and quantitation of human fibrinogen in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.

Features:

  • No-wash steps, no separation steps
  • TR-FRET technology
  • Sensitive detection
  • High reproducibility
  • Faster time-to-results
  • Easy automation
  • 96-well, 384-well, and 1536-well formats

LANCE and LANCE (Lanthanide chelate excite) Ultra are our TR-FRET (time-resolved fluorescence resonance energy transfer), homogeneous (no wash) technologies. One antibody of interest is labeled with a donor fluorophore (a LANCE Europium chelate) and the second molecule is labeled with an acceptor fluorophore (ULight™ dye). Upon excitation at 320 or 340 nm, energy can be transferred from the donor Europium chelate to the acceptor fluorophore if sufficiently close for FRET (~10 nm). This results in the emission of light at 665 nm.

Matrix Metalloproteinase 10 (MMP10) is also known as stromelysin-2 or transin-2. MMPs are involved in the breakdown of the extracellular matrix in normal physiological processes. MMP10 is secreted in a “proMMP10” form with is cleaved by other extracellular proteinases to become active. MMP10 has been linked to cancer stem cell vitality and metastasis and has been tabbed as a potential marker in oral cancer.

Specifications

Assay Target MMP10
Assay Target Class Protein
Automation Compatible Yes
Detection Method Time-Resolved Fluorescence (TRF), TR-FRET
Product Brand Name LANCE Ultra
Shipping Condition Blue Ice
Target Species Human
Therapeutic Area Cancer
Unit Size 10,000 Assay Points