PerkinElmer
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Glucagon, Receptor Grade, [125I]-, 10µCi

Glucagon, labeled with 125I. This product is receptor grade, and was developed for use in receptor binding assays. Glucagon binds and activates glucagon receptor, a GPCR that is a potential drug target for diabetes, hyperplasia, and pancreatic disorders.

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Unit Size
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NEX207010UC
10 µCi
1028.00 USD
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NEX207050UC
50 µCi
2171.00 USD
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Detail Information

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX207:

  1. Bizeau, M.E. & Hazel, J.R., (2000), Membrane physical properties do not explain increased cyclic AMP production in hepatocytes from rats fed menhaden oil, Lipids, 35: 595-600.
  2. Lee, C., Hamm, M.W., (1989), Effect of Dietary Fat and Cholesterol Supplements on Glucagon Receptor Binding and Adenylate Cyclase Activity of Rat Liver Plasma Membrane, The Journal of Nutrition, 119 (4): 539–546.

Specifications

Concentration 85.1 µCi/mL
Detection Method Radiometric
Fresh Lot Days First Monday of each month
Label Position Nominally Labeled
Molecular Weight 3608.0
Product Brand Name NEN Radiolabeled Ligands
Radioisotope I-125
Radionuclide 125I
Receptor Type Glucagon
Shipping Condition Ambient
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area Diabetes
Unit Size 10 µCi