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Ethylcarboxamidoadenosine, 5`-N-[Adenine-2,8-3H]-, 250µCi (9.25MBq)

5'-N-Ethylcarboxamidoadenosine (NECA), tritiated at the adenine-2,8 position. 5'-N-Ethylcarboxamidoadenosine is an adenosine analog that acts as an agonist at adenosine receptors A1, A2A, and A3.

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NET811250UC 1581.00 USD
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5'-N-Ethylcarboxamidoadenosine acts as an agonist at adenosine receptors, and is a vasodilator. Adenosine receptors are a group of GPCRs that play a role in blood flow.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET811:

  1. G S Firestein, D A Bullough, M D Erion, R Jimenez, M Ramirez-Weinhouse, J Barankiewicz, C W Smith, H E Gruber, K M Mullane. Inhibition of neutrophil adhesion by adenosine and an adenosine kinase inhibitor. The role of selectins. The Journal of Immunology January 1, 1995, 154 (1) 326-334.


Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 308.28
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Adenosine
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Cardiovascular, Inflammation, Metabolic Disorders
Unit Size 250 µCi