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EnVision 2105 Multimode Plate Reader

The EnVision 2105 multimode plate reader provides exceptional speed, ultra-high throughput, and maximum sensitivity across all detection technologies. Tried and tested, the EnVision microplate reader gives you robust performance and reliable data for high throughput screening, time after time.

The EnVision 2105 model delivers even higher sensitivity for time-resolved fluorescence (TRF) applications, and the Enhanced Security software option includes tools to facilitate 21 CFR Part 11 compliance for integration into regulated environments (GxP). In addition, the Alpha 775 laser module is designed for plant assays.

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Our gold-standard for high-throughput screening, the EnVision provides exceptional sensitivity and speed with minimal downtime – backed by our global network of application scientists and engineers.

Our Alpha and LANCE® reagents are developed and optimized on the EnVision plate reader so you can be confident of accurate results. Plus, we can cite over 15,000 published papers that attest to its real-world performance across a broad range of applications.

  • Our state-of-the-art, dual-detector model is among the fastest HTS readers in the market
  • Choose from detection technologies including AlphaScreen®, AlphaLISA®, fluorescence, ultra-sensitive luminescence, absorbance, time-resolved fluorescence (TRF) and TR-FRET, for example to detect PerkinElmer’s DELFIA and LANCE assay technologies
  • Maximum speed and sensitivity with proprietary Direct Optics technology
  • Hybrid system combining filters for sensitivity and monochromators for assay flexibility
  • Laser excitation technology for time-resolved fluorescence modes for the best available TRF performance
  • Laser technology for high throughput for AlphaScreen assays
  • Low detection levels for high throughput screening applications so you can be confident that you are not missing any leads.

Two configurations are available, which both offer the same unsurpassed sensitivity and analytical performance

  • The EnVision 2105 HTS multimode plate reader - a super-fast, dual-detector reader designed specifically to support demanding high-throughput discovery applications.
  • The EnVision 2105 XCite multimode plate reader – a single-detector system ideal for the most challenging research and assay development applications. The EnVision  XCite multimode plate reader is upgradeable to the EnVision HTS multimode plate reader.

Technologies included

  • Filter based fluorescence intensity (top and bottom)
  • Time-resolved fluorescence (top and bottom)
  • Luminescence, including glow, flash and dual luminescence
  • Filter-based absorbance
  • Fluorescence Polarization

Optional technologies

  • Standard AlphaLISA®/AlphaScreen®/Alpha (680nm Laser excitation)
  • High-throughput AlphaLISA®/AlphaScreen®/Alpha (680nm or 775nm Laser excitation)
  • Monochromator-based fluorescence intensity
  • Monochromator-based absorbance detection
  • Laser-based time-resolved fluorescence
  • Ultra-sensitive luminescence

​​Key Features

  • Proprietary Direct Double Optics deliver a full lens system for maximum speed and sensitivity (EnVision 2105 HTS system only)
  • The fastest mode uses an innovative "on the fly"-detection - making EnVision exceptionally fast in measuring absorbance or fluorescence intensity on a 1536-well plate - less than 36 seconds including plate loading times
  • Field upgradeable for changing application needs
  • User-changeable, label-specific optical mirror modules and filters for assay customization with positive identification of measurement configuration (barcodes)
  • Integrated barcode reading enables barcode reading from short right side and both long sides of the plate
  • Optional 21 CFR Part 11 support


  • 2 channel dispenser
  • Plate stacker (20 or 50 plates)
  • Temperature control up to 55ºC
  • Compatible with a wide range of automation systems
  • Spotfire® Analyst for Multimode Detection (MMD) is tailored to the analysis of plate reader data and enables you to visualize, correlate, compare and analyze your data and share freely with your colleagues

Outstanding Support

We understand your science and applications. Combine many years’ experience developing and supporting multimode plate readers and reagents with a global network of application scientists and engineers, and you can be confident of minimal downtime.

You can also access our Application Support Knowledge base (ASK) which provides a comprehensive set of technology-specific and application-specific scientific articles, written by our R&D, technical support, and applications teams, enabling you to access scientific support 24 hours a day/7 days a week.

Part of a Total Solution for Screening

EnVision is part of our complete solution for screening. For high-throughput screening, we offer assays and reagents, radioimmunoassays and radiometric detection, microplates and automation, in addition to multimode plate readers. We also offer solutions for phenotypic screening such as high-content screening systems and for data analysis such as Signals for Screening.

Recent publications:

  • Antibody profiles to wheat germ cell-free system synthesized Plasmodium falciparum proteins correlate with protection from symptomatic malaria in Uganda. Kanoi, Bernard N et al. Vaccine (2017), 35(6): 873-881. doi 10.1016/j.vaccine.2017.01.001.
  • Novel Small Molecule Entry Inhibitors of Ebola Virus. Basu, Arnab et al. The Journal of Infectious Diseases (2016), 212 Suppl 2:S425-34. doi: 10.1093/infdis/jiv223.
  • A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein. Landeck, Natalie et al. Molecular Neurodegeneration (2016), 11(1):61. doi: 10.1186/s13024-016-0125-0.
  • Signal transduction pathways activated by insulin-like peptide 5 at the relaxin family peptide RXFP4 receptor. Ang, Sheng Y. et al. British Journal of Pharmacology, (2016), doi: 10.1111/bph.13522.
  • Development of two novel high-throughput assays to quantify ubiquitylated proteins in cell lysates: application to screening of new anti-malarials. Mata-Cantero, Lydia et al. Malaria Journal (2015), 14:200. doi: 10.1186/s12936-015-0708-1.
  • Effect of protein aggregates on characterization of FcRn binding of Fc-fusion therapeutics. Bajardi-Taccioli, Adriana et al. Molecular Immunology (2015), 67(2 Pt B):616-24. doi: 10.1016/j.molimm.
  • Aptamer-mediated nanoparticle interactions: from oligonucleotide-protein complexes to SELEX screens. Evadé, Laetitia et al. Methods in Molecular Biology (2015), 1297:153-67. doi: 10.1007/978-1-4939-2562-9_11.
  • Autoantibody Profiles in Collagen Disease Patients with Interstitial Lung Disease (ILD): Antibodies to Major Histocompatibility Complex Class I-Related Chain A (MICA) as Markers of ILD. Furukawa, Hiroshi et al. Biomarker Insights (2015), 10:63-73. doi: 10.4137/BMI.S28209.
  • Structural basis of AMPK regulation by adenine nucleotides and glycogen. Li, Xiaodan et al. Cell Research (2015), 25(1):50-66. doi: 10.1038/cr.2014.150.
  • Serologic assay for diagnosis of celiac disease based on a patient-derived monoclonal antigliadin antibody. Steinsbø, Øyvind et al. Gastroenterology (2015), 149(6):1530-1540.e3. doi: 10.1053/j.gastro.2015.07.008.

Disclaimer:  For research use only. Not for use in diagnostic procedures.


21 CFR Part 11 Compatible Yes
Automation Compatible Yes
Detection Method Absorbance, Time-Resolved Fluorescence (TRF), Luminescence, Alpha, Fluorescence, Fluorescence Polarization
Product Brand Name EnVision

Resources, Events & More

All (23)
Resource Type File Name File Format
Brochure Drug Discovery Screening Solutions Brochure PDF  880 KB
Brochure EnVision Multimode Plate Reader Brochure PDF  3 MB
Brochure Multimode Plate Reader Portfolio Brochure PDF  1 MB
White Paper Guidance for Ensuring your EnVision Multimode Plate Reader Complies with 21 CFR Part 11 PDF  801 KB
Application Note Advantages of Wavelength Scanning in Fluorescence and Absorbance Assays PDF  393 KB
Application Note AlphaLISA GMO Protein Detection Seed Extract PDF  1 MB
Application Note Performing AlphaLISA Assays with RPMI-1640 PDF  604 KB
Application Note α-Fetoprotein Assay on Dried Blood Spot for Hepatoblastoma Screening in Children with Overgrowth-Cancer Predisposition syndromes PDF  199 KB
Technical Note Enhancement of BRET2 Assay Robustness and Handling Utilizing the PerkinElmer EnVision Plate Reader PDF  975 KB
Technical Note Normalization of Luminescence Assays Using Glowell Microplate Standards, ATPLite Luminescence Assay Kit and EnVision Multilabel Plate Readers PDF  530 KB
Technical Note Photometric Assays with Envision Multilabel Plate Reader PDF  312 KB
Poster AlphaLISA Quantification and Characterization of BioTherapeutic Proteins and Process Contaminants PDF  653 KB
Poster AlphaLISA® Technology and the SciStream™ Add-on for TIBCO Spotfire® PDF  1 MB
Poster Characterization of Intractable Epigenetics Targets Using Homogenous Immunoassays PDF  1 MB
Poster Comparison of endogenous methyl marks on histone H3 in cancer-derived cell lines using AlphaLISA PDF  1 MB
Poster Development of New AlphaLISA No-wash Immunoassay Kits for Sensitive, Rapid and Efficient Quantification of Cytokines PDF  279 KB
Poster Efficient AlphaLISA immunoassays for the detection and characterization of monoclonal antibody biotherapeutics PDF  525 KB
Poster High Sensitivity cAMP Assays in Primary Cells and Mesenchymal Stem Cells with the LANCE® Ultra cAMP kit PDF  114 KB
Poster Simultanous detection of IL-6 and IL-8 secretion by cell lines using Alpha technology PDF  528 KB
Poster Tau Duplex: A novel assay to detect phosphorylated and total tau protein in neuronal cells using Alpha technology PDF  515 KB
Poster Use of the JANUS Automated Workstation to Develop Efficient AlphaLISA Immunoassays for Isotyping Human Monoclonal Antibodies PDF  1 MB
Application Note Simultaneous Detection of Total and Phosphorylated Protein in Cellular Kinase Assays Link
Support Portal Application Support Knowledgebase Link