The EnSight™ multimode plate reader offers HTS Alpha, Ultra-sensitive Luminescence and fast well-imaging technologies alongside conventional multimode detection technologies. Imaging & online data analysis is fast: a 384-well plate can be imaged in less than 5 mins. The system’s modular design, combined with workflow-based Kaleido™ data acquisition & analysis software, gives a truly versatile plate reader that gets users productive quickly.
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The EnSight system's cell-imaging option, brings image-based cytometry together with our industry-leading detection technologies for the first time. Imaging is fast, with online data analysis in minutes.
The system has a modular design that lets you add detection modes as your needs change, and combined with workflow-based Kaleido™ data acquisition and analysis software, you have a truly versatile plate reader that gets users productive quickly – making it ideal for multiuser environments.
Our Enhanced Security option for the Kaleido software provides technological controls and features that support 21 CFR Part 11 compliance. It empowers users based on their authorization level to assign access, implement data security, approve workflows with electronic signatures, and view all user actions from a comprehensive audit trail.
Technologies:
Key Features:
| Automation Compatible | Yes |
|---|---|
| Detection Method | Absorbance, Image-based Cytometry, Time-Resolved Fluorescence (TRF), Luminescence, Alpha, Fluorescence |
| Product Brand Name | EnSight |
In this application note, the imaging module of EnSight® multimode plate reader was used to automatically detect the viability of Arabidopsis thaliana, a model organism often used by plant biologists for different research purposes.
A custom script created for the Kaleido software was used to detect seeds at early stages of the germination process: brightfield and fluorescence images were used to count seeds and to automatically compute the percentage of germinated seeds present in each well. Seed germination was modulated by treating seeds with different concentration of the plant hormone abscisic acid or NaCl (salinity stress). MyAssays® Desktop was used for analysis of the kinetic data, that were automatically acquired every 4 hours by EnSight.
The traditional approach based on visual inspection of germinating seeds is time-consuming and has limitations. But with the automated approach, the EnSight can accelerate the quantification of the germination rate of A. thaliana seeds, generating reproducible and robust results. Read this application note to learn more.
High throughput screening (HTS) in iPSC (induced pluripotent stem cells)-derived neuronal cell types with the intent to identify novel therapeutic compounds for neurodegenerative diseases has the potential to transform the way drug discovery is performed. But the use of neuronal stem cells for screening campaigns has unique challenges, as they require long-term cultivation. With increasing cultivation times, the risk of cell contamination and clustering also increases. These factors have significant impact on assay performance and are important to detect early as they can quickly become cost-prohibitive for HTS campaigns.
Learn how our EnSight® multimode plate reader can mitigate these risks by providing live cell imaging analysis and quality control testing as Evotec and PerkinElmer have jointly developed an automation platform for generating iPSC-derived cultures at industrial scale.
A variety of chemotherapeutic drugs with different modes of action have been developed and tested as potential therapies for colorectal cancer. Characterizing the effects of potential drugs with different modes of action is a key part of the process.
In this application note you will learn:
Download our brochure to learn how our solutions help you to grow, detect, and analyze 3D cells.
Find out about our range of integrated solutions for drug discovery screening in this e-brochure.
Our screening solutions for high-throughput screening, phenotypic screening and data analysis help to streamline drug discovery workflows in labs across the globe. Our portfolio includes automated liquid handling, assays and reagents, imaging and detection systems, and informatics.
Working independently or together, with our solutions you can achieve consistent and accurate results. By accelerating the identification and characterization of effective and safe drug candidates, the PerkinElmer portfolio enables you to optimize efficiency in your lab and deliver more actionable, real-world results.
Download the brochure to learn more about how we can partner with you so that you can discover smarter, more effective, data-driven breakthroughs in the critical screening stages of drug discovery and development.
Selecting the right plate reader for your lab can be challenging. There are multiple factors to consider including: detection type, additional features, support, and price. With numerous options for each variable, it can be confusing to navigate the selection process. Focusing on striking a balance between functionality, optimization, and growth potential requires keen insight and continued vendor support throughout the life cycle of the plate reader.
This detailed guide will help you choose the right plate reader for your needs by examining the marketplace and pointing out considerations to keep in mind when making your decision.
Reaching compliance according to the laws and regulations of each country can be a tedious, complicated process, and being GxP compliant (FDA 21 CFR Part 11, EU Annex 11, etc.) is necessary in order to deliver therapeutic treatments to market for pharmaceutical and biotechnology companies, including clinical research organizations.
Simplify compliance for your VICTOR® Nivo™, EnSight®, or EnVision® multimode plate reader with the help of our Enhanced Security software. In addition, our wide range of assays can help you achieve your research goals, and our qualification services will make sure your multimode plate reader and software are operating at the recommended technical specifications.
To guide you through the complexity of the compliance process, we can help with our proven solutions, customer training, and technical support so you can focus on your science and research.
High sample density microplate reader technology combined with high sensitivity, time-resolved fluorescence (TRF) measurement, contribute to research in monitoring and studying the effects of various environmental stressors on Baltic Sea flora
Report presents a method EnSpire™ Multilabel Plate Reader to detect environmental stress levels in organisms at the base ofthe marine food web. It shows results from 8 L. macrurus samples collected from one study site
Plaque assays are a standard method utilized by virologists to identify the amount of infectious virus particles in solution. In many laboratories, counting the plaques in plates is performed manually either by visual inspection or using a microscope. This is cumbersome, error prone and very time-consuming. Automated imaging and plaque analysis are rarely used.
In this note, we show how the plaque imaging and analysis process can be automated to help virologists rapidly determine the concentrations of virus solutions with higher precision and less effort using the EnSight® multimode plate reader and Kaleido™ Data Acquisition and Analysis Software. When combined with 96-well microplates and EnSight’s stacker system, this method further enhances the time-saving benefit and qualifies for high-throughput screening (HTS) applications. Download our technical note to learn more.
To achieve compliance with the regulations of the Food and Drug Administration (FDA) as defined in the 21 CFR Part 11 and other references like the EU Annex 11, you need a well aligned combination of software tools and implemented administrative procedures. With the Enhanced Security option for the EnSight® multimode plate reader software, PerkinElmer provides a variety of tools to simplify your road towards compliance.
This white paper gives an overview of the features and tools provided by the Enhanced Security option for EnSight's Kaleido™ software with reference to the relevant paragraphs of 21 CFR Part 11.
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