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DTG (1,3-Di-o-tolylguanidine, [p-ring-3H]-), [5-3H(N)]-, 1mCi (37MBq)

DTG (Ditolylguanidine), tritiated on the p-ring and at the 5- position. DTG is a selective sigma receptor (σ-receptor) agonist.

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NET986250UC
250 µCi
2171.00 USD
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NET986001MC
1 mCi
5500.00 USD
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Detail Information

Ditolylguanidine acts as an agonist at sigma receptors (σ1 and σ2), and has neuroprotective and antidepressant effects.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET986:

  1. Dhwanil A. Dalwadi, Seongcheol Kim, John A. Schetz, Activation of the sigma-1 receptor by haloperidol metabolites facilitates brain-derived neurotrophic factor secretion from human astroglia, In Neurochemistry International, Volume 105, 2017, Pages 21-31.
  2. Diaz, J. L.; Christmann, U.; Fernandez, A.; Torrens, A.; Port, A.; Pascual, R.; Alvarez, I.; Burgueno, J.; Monroy, X.; Montero, A. Synthesis and Structure-Activity Relationship Study of a New Series of Selective σ1 Receptor Ligands for the Treatment of Pain: 4-Aminotriazoles J. Med. Chem. 2015, 58, Pages 2441– 2451.

Specifications

Detection Method Radiometric
Label Position Nominally Labeled
Molecular Weight 239.32
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Cancer
Unit Size 1 mCi
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Radiometric Reagents Guide 2010-2011

For over 50 years PerkinElmer has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed today.

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