PerkinElmer
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DOFETILIDE, [N-METHYL-3H], 100 µCi

Dofetilide, tritiated at the N-methyl position. Dofetilide is a selective potassium channel (hERG) blocker.

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NET1144100UC 1575.00 USD
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Overview

Dofetilide acts as a selective potassium channel (hERG) blocker, and is used as an antiarrthythmic drug. The hERG ion channel is involved in the electrical activity of the heart's beating, and is an important antitarget to avoid during drug development.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1144:

  1. Steven M. Murphy, Marc Palmer, Michelle Fontilla Poole, Linas Padegimas, Karen Hunady, Joel Danzig, Sikander Gill, Rajwant Gill, Anthony Ting, Bruce Sherf, Kurt Brunden, Alain Stricker-Krongrad, Evaluation of functional and binding assays in cells expressing either recombinant or endogenous hERG channel, In Journal of Pharmacological and Toxicological Methods, Volume 54, Issue 1, 2006, Pages 42-55.

Specifications

Detection Method Radiometric
Label Position Specifically Labeled
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type hERG
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area Cardiovascular, Cancer
Unit Size 100 µCi