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Deltorphin II(2-D-Ala), [Tyrosyl-3,5-3H]-, 50µCi (1.85MBq)

Deltorphin II, tritiated at the tyrosyl-3,5 position. Deltorphin II is a selective δ opioid receptor (DOPR) agonist.

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Part Number Unit Size List Price Your Price Quantity
NET1087050UC 50 µCi 913.00 USD
NET1087250UC 250 µCi 3866.00 USD
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Overview

Deltorphin II is a delta opioid receptor agonist. These receptors belong to a group of GPCRs proposed to play a role in analgesia and mood. They are potential drug targets for pain and depression.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1087:

  1. Heather L. Handl, Josef Vagner, Henry I. Yamamura, Victor J. Hruby, Robert J. Gillies, Development of a lanthanide-based assay for detection of receptor–ligand interactions at the δ-opioid receptor, In Analytical Biochemistry, Volume 343, Issue 2, 2005, Pages 299-307.

Specifications

Concentration 1.0 - 10 mCi/mL
Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 782.9
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Opioid
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Pain, Inflammation
Unit Size 50 µCi