Designed for fast-paced, high-volume laboratories that need to increase analytical cycle times, the Clarus 690 GC provides superior sensitivity, capacity, and throughput – with flexibility to handle more. Our industry-leading portfolio of TurboMatrix™ options include headspace (HS), manual and automated thermal desorption (TD, ATD) and MultiPrep Autosampler solutions.
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When the highest levels of throughput are critical to your operations, choose the Clarus 690 gas chromatograph. Its patented high-performance oven delivers the fastest heat-up and cool-down of any oven in the business, and that means shorter injection-to-injection times, and the ability to run more samples per day. Plus, the oven’s twin-wall design with concentric air exhaust provides exceptional cooling to near-ambient temperatures without resorting to liquid cryogen – critical for analysis of VOCs. The Clarus 690 GC features a wide-range flame ionization detector (FID), a new high-performance capillary injector with decreased reactivity, and autosampler technology that delivers multiple options for liquid injection, headspace, and SPME on one system.
This system is driven by our TotalChrom™ chromatography data system (CDS) that serves as both an instrument controller and a data management system, making it the best choice for data handling in demanding multiuser, multisite environments where a number of instruments are in use. Plus, the TotalChrom system’s unique data protection features ensure that data acquisition processes aren’t disrupted or compromised. Plus, our GC instruments feature an intuitive touch-screen interface with real-time signal display and eight-language support for greatly simplified user interaction.
The calibration/Internal standards are available but must be ordered separately.
The purpose of this app note is to apply novel oven technology, a short GC column and high oven heating and cooling rates to a modified 8015 DRO method.
Air pollution is a global concern. Ground-level ozone has become an increasingly important issue in developed nations, as the health effects of smog are more clearly understood. The monitoring of VOC ozone precursor compounds will continue to play a role in defining and reducing air pollution in developed and developing nations in the next decade. The data presented here shows the excellent results of improved separation via Elite-624Sil MS column with real world samples, simplified column connections to the Dean Switching device and trap with modernized triple bed trap with guard zone technologies.
The use of Food Contact Materials (FCM) can potentially be detrimental to human health. In the PerkinElmer quantification of Phthalate Leaching from FCMs, using the Clarus GC/MS, we explore how to quantify FCMs.
Optimized methods are needed for the analysis of toxic compounds in air to understand the impact to human health. People breathe approximately 20,000 liters of air a day so this concern is significant. EPA Method TO-17 is used to determine toxic compounds in air after they have been collected onto sorbent tubes. This application note demonstrates that the PerkinElmer TurboMatrix™ Thermal Desorber and the PerkinElmer Clarus® SQ 8 GC/MS will meet and exceed the criteria set forth in EPA method TO-17. Detailed instrument method parameters are presented, with precision, recovery, linearity and detection limit results.
The European Union directives assist the member states to define the activities to be programmed and the objectives to be achieved. In this framework, the chemical analysis of the water system is the main activity to preserve the healthiness of the waterways through monitoring and detection of substances that are harmful to the environment and to the health of citizens.
This application shows this framework could be achieved with GC/MS analysis.
Although considered pharmacologically inert, pharmaceutical excipients have been shown to interact with active drug substances to affect the safety and efficacy of drug products.Therefore, there is an increasing awareness of the necessity to understanding interactions between excipients and the active pharmaceutical ingredient (API) in finished dosage forms.
The PerkinElmer® TurboMatrix™ Headspace Trap system coupled with a Clarus® SQ 8 GC/MS is a very convenient means of identifying low concentration volatile organic compounds (VOCs) in foodstuffs. In this application note, the VOCs in various fruit juices were investigated. Sample preparation simply involved dispensing a fixed volume of fruit juice into a sample vial and sealing it. The analysis was fully automated.
Malodor pollution in water has emerged as an increasingly worrisome consequence of continued worldwide urbanization and industrialization. Volatile organic sulfur compounds (VOSCs), such as dimethyl disulfide (DMDS) and dimethyl trisulfide (DMTS), have been identified as a primary contributor to malodor pollution in water, and are considered a serious safety and environmental threat, rendering drinking water sources unpalatable. In this study, a method for the determination of DMDS and DMTS in water was established using a PerkinElmer Clarus® GC/FPD with the TurboMatrix™ HS-40 Trap. The methodology offers a simple, sensitive and efficient means of detecting DMDS and DMTS in water.
The existing ASTM® D4815 method is designed to monitor oxygenated compounds in gasoline at percentage concentrations. The method described in this application note is intended to enable these analytes to be monitored down to low-ppm concentrations.
ASTM® D7059-04 is an established method that has been well validated for the determination of methanol in crude oils. In this application note, a method based on a PerkinElmer® Clarus® 600 GC with an S-Swafer™ splitting device is described.
Thymopentin (TP5), a 5-amino-acid polypeptide, is a safe and effective immunostimulant utilized in the treatment of a variety of immune disorders. Several residual solvents are used in the manufacture of TP5, including the "universal solvent" N,N-dimethylformamide (DMF), known for its high solubility to a variety of organic compounds. United States Pharmacopoeia has established an 880 ppm maximum concentration level for DMF to reduce potentially negative influences on the human body. This application note describes a GC/FID method for the determination of DMF utilizing a PerkinElmer Clarus® 680 GC/FID with TurboMatrix™ HS-40. The method offers a simple, sensitive and efficient means of detecting DMF with good linearity, repeatability and low reporting limits.
Volatile organic compounds (VOCs) are a series of compounds with high vapor pressure and boiling points from 50 to 250 degrees centigrade. These characteristics lead to the tendency for large numbers of molecules to evaporate, or volatilize, from their solid state into the air. VOCs are present in the environment from a number of sources, both anthropogenic and naturally occurring. In soil, VOCs are mainly derived from discharged industrial and domestic sewage, oil spills, and chemical solvent leakages. Monitoring of VOC contamination in soils by both qualitative and quantitative analyses is important to ensure that the potential negative health impacts of VOC exposure are mitigated. In this study, thirty seven VOCs are investigated in a soil matrix, using a PerkinElmer Clarus® GC/FID and TurboMatrix™ HS-40. Detailed instrument method parameters are presented with precision, linearity and reporting limit results.
As an alternative to tetraethyl lead, t-Butyl methyl ether (MTBE) has been widely used as an octane enhancer for gasoline. Studies have found increasingly high levels of MTBE in groundwater, often a result of accidental spills or leaking underground storage tanks. In this paper, a method for the determination of MTBE in water and soil was established using the PerkinElmer Clarus® 690 GC/FID with the TurboMatrix™ HS-40 Trap.
EPA 8015C is a gas chromatographic method used to establish concentrations of a variety of non-halogenated volatile organic compounds, semivolatile organic compounds, and petroleum hydrocarbons. For the purpose of this application, a Clarus® 690 GC was used for the analysis of petroleum hydrocarbons, specifically Diesel Range Organics (DRO).
To meet the demands of complex petrochemical testing, our new Clarus® 590 and 690 gas chromatography (GC) instruments are preconfigured to provide a turnkey solution for a wide range of applications, including Simulated Distillation. We deliver a complete, ready-to-go system for faster, more efficient analysis in compliance with ASTM methods. Discover how the Clarus GC instruments enable the superior sensitivity and throughput you need for your most critical applications – plus the versatility to handle more.
The contamination of aviation fuel with fatty acid methyl esters (FAMEs) can arise due to the use of multi-product pipelines for fuel supply and distribution. This application note demonstrates the use of the Clarus 600 GC/MS to identify and determine the contamination.
Customer complaints of odors within a new car are rising with the increasing number of new car buyers. Although odors can be subjective, it is now well known that the new car smell is the result of chemicals emitted from the in-vehicle interior components such as the dashboard, interior panels, seat coverings, flooring materials, and so on. This application note describes a method for the automotive industry that provides a qualitative analysis and the olfactory character of each component using the TD-GC/MS-Olfactory Port.
The rapid development of natural ,gas from unconventional sources in ,North America has created an energy ,“gold rush” not seen in contemporary ,times. The advent of horizontal drilling ,technologies and hydraulic fracturing has ,made this production economical and ,presents an energy source of sufficient ,magnitude that could last 100 years.
Crude Palm Oil (CPO) is a raw material used in the production of margarine and other vegetable oil based food products. CPO is traded and there are quality specifications based on free fatty acids (FFAs) as well as moisture and impurities. Margarine manufacturers also want to assess the CPO’s ‘fitness for refining’ which is measured by the Deterioration of Bleachability Index (DOBI). A DOBI index of less than 1.8 indicates a poor quality oil; a DOBI index > 3 indicates a high quality oil.
Today’s plastics are some of the most used materials on a global volume basis. Broadly integrated into today’s industrial and commercial lifestyles, they make a major, irreplaceable contribution to virtually every product category.
In this compendium you will find a wide range of applications for polymers, plastics, rubbers and advanced materials. Discover how to put these applications to work for you simply and efficiently.
Residual solvents are used in the manufacture of active pharmaceutical ingredients (APIs), excipients, or in preparation of drug products, and are not removed during the purification processes. Residual solvents are one of the three main impurities in pharmaceutical materials; the other two are organic and inorganic impurities. Residual solvents do not provide any therapeutic benefit and should be removed to the extent possible, fulfilling quality-based requirements as per International Conference on Harmonization (ICH) guidelines – this is one of the standards to control the quality and the purity of the pharmaceutical substances, excipients, or drug products.
This paper will demonstrate the analysis of all three classes of residual solvents by pressure-balanced headspace sample introduction and GC-FID analysis. In addition to a discussion of the instrumental technique, the choice of the diluent will also be studied; two diluents will be used throughout.
Residual solvents are used in the manufacture of active pharmaceutical ingredients (APIs), excipients, or in preparation of drug products and are not removed during the purification processes. Residual solvents are one of the three main impurities in pharmaceutical materials.
Residual solvents do not provide any therapeutic benefit and should be removed to the extent possible, fulfilling quality based requirements as per International Conference on Harmonization (ICH) guidelines – this is one of the standards to control the quality and the purity of the pharmaceutical substances, excipients, or drug products.
This paper will demonstrate the analysis of all three classes of residual solvents by pressure-balanced headspace sample introduction and GC-FID analysis.
Although considered pharmacologically inert, pharmaceutical excipients have been shown to interact with active drug substances to affect the safety and efficacy of drug products. One of the areas of major concern is the potential chemical interaction between impurities in the excipient and the drug molecules, leading to the formation of reaction products. Formaldehyde present in excipients has been implicated in the degradation of several drug products where it can form adducts with primary and/or secondary amine groups. It has also been reported that formaldehyde can induce cross-linking in gelatin capsules causing an adverse effect on in-vitro dissolution rates of drugs.
This application note presents a simple and effective method for the determination of formaldehyde in pharmaceutical excipients using SHS-GC/MS. The method is fast, reliable and can be used for the quantification of low-molecular-weight aldehydes in most excipients commonly used in pharmaceutical products.
With an inherent toxicity, a tendency to accumulate in the food chain and a particularly low removal rate through excretion, lead (Pb), cadmium (Cd) and arsenic (As) cause harm to humans even at low concentrations.
Ethylene oxide (EO) is a highly reactive, toxic and flammable gas which can act as an irritant to humans at room temperature. Since the 1950s, EO has been utilized for the sterilization of medical instruments that cannot be exposed to moisture or high temperatures, including those made of polymers, plastics or those containing electronic components. Although the EO method ensures medical instruments can be sterilized without the deleterious effects of high-temperature sterilization, potentially dangerous side effects are possible, namely owing to the hazardous nature of the chemical.
In this application note, a rapid analytical method for the determination of EO in medical supplies was established using a PerkinElmer Clarus® GC/FID with the TurboMatrix™ HS-40. Empower® software was utilized throughout the entire experiment. This method demonstrates results with high efficiency, good linearity, sensitivity and repeatability for EO analysis.
The synthesis of active pharmaceutical ingredients(API) may require multiple reaction steps that produce undesirable reaction byproducts or utilize various solvents that have to be removed from the finished product. These solvents and byproducts may be measured with headspace gas chromatography for those volatile residual organic solvents according to the USP chapter 467 method.
This application note describes a method that is based on the original ASTM® D-3606 method with the main difference being that capillary columns are used. This approach completely eliminated all chromatographic interference from the ethanol (even solutions made up in pure ethanol could be run), improved the quality of the chromatography in general and reduced the analysis time significantly (by 50% or 75% depending on the column set).
The determination of light hydrocarbons in refinery and other gases is typically performed through the use of packed columns and mechanical rotary valves. For example ASTM Method D-2597 adopts this approach. A gas sampling valve delivers a small metered quantity of the sample gas into a non-polar packed column. The C1 to C5 hydrocarbons are allowed to elute from this column and into a second packed column with a polar stationary phase. At that point a rotary valve is actuated to reverse the flow of carrier gas through the precolumn and backflush any residual sample in that column to a detector to determine the total C6+ content in the sample. In the meantime, chromatography of the C1 to C5 content proceeds on the second column for separation, identification and quantification. The whole analysis takes about 20 minutes and getting acceptable chromatographic separation is often a challenge because of normal variations in the columns. In this application note, a new method is described for this analysis that uses a Swafer™ backflushing technology with capillary columns under isothermal conditions to both improve the chromatographic separation and to reduce the analysis cycle time to just over 5 minutes.
ASTM® Test Method, D2427-06, is designed to determine the C2 to C5 hydrocarbon content in gasolines. This method validates gasoline samples that are depentanized using ASTM® method D2001-07. These samples are intended for functional group hydrocarbon analysis by mass spectrometry according ASTM® Test Method D2789-95 (2005).
In today’s budget-constrained, yet highly competitive laboratory environments, the samples you’re being asked to analyze - whether food, pharmaceutical, petrochemical, or environmental - are increasingly difficult. But for some labs, having a dedicated GC for every application isn’t an option. For them, a GC that can do it all isn’t just a nice-to have, it’s a necessity.
Innovation is the lifeblood of industrial polymer development – the push to improve materials or develop new ones infuses new life into the industry from R&D through to QA/QC. Manufacturers are continually challenged to ensure effective quality control and streamline processes while meeting stringent standards. Increasingly they must design for recycling and/or reuse in an ever more waste-adverse economy, keep a watchful eye on costs and stay ahead of the competition.
In response, we've gained years of experience developing a range of analytical capabilities to address a wide range of polymer analysis needs.
Download the interactive brochure to learn more about the most common challenges and our solutions in the market.
The Deepwater Horizon oil spill has contaminated parts of the Gulf of Mexico and estuaries in several coastal states in the southern region of the US.
Increasing demands for efficiency, productivity, data quality, and profitability pose ongoing challenges for lubricant testing labs, like yours. Whether you need to achieve quick turnaround times, minimize downtime, or maximize lab efficiencies, you can rely on PerkinElmer for a comprehensive set of simple-to-use and proven testing solutions to help you achieve accurate results in record time. Learn more about our solutions.
Oil refineries and natural gas producers around the world require their lab operations to perform large numbers of analyses before their products are used in industries and by consumers. Detection of even the slightest impurities, accurate process control and hydrocarbon distribution analysis is critical to the success of these operations.That’s how PerkinElmer can help. As a global scientific leader and solutions provider to refining and natural gas labs, PerkinElmer's proven technology and experience meets the ever-changing needs of the oil and gas industry. PerkinElmer is committed to the success of your oil and gas sample analysis by providing the instrumentation, software, consumables, and services you need for fast, easy and precise testing. The result: better control of your operations and improved product quality.
Headspace Gas Chromatography—for applications involving the solvent-free extraction of volatile compounds, it’s an unsurpassed technique, eliminating the time-consuming steps and risk of human error associated with other GC sample-preparation methods.
This report shows an example of three general degradation processes. The analytical system consisted of a Clarus GC/MS interfaced with a Pyrolysis Autosampler. Samples are rapidly pyrolyzed, automatically introduced into the GC carrier stream
Increasing demands for efficiency, productivity, data quality, and profitability pose ongoing challenges for lubricant testing laboratories, like yours, performing new lubricant or in-service oil analyses.
Whether you need to achieve quick turnaround times, minimize downtime, or maximize lab efficiencies, you can rely on PerkinElmer as a trusted partner for simple-to-use and reliable testing solutions.
Partnering with leading global standards organizations and hundreds of oil laboratories, we continually address laboratory needs and ever-changing standards while developing new methods and protocols that conform with ASTM®, regulatory, and customer-defined requirements.
Download this infographic to learn more about our broad range of proven lubricant testing solutions.
Poster summarizing solutions of thermal analysis, molecular spectroscopy, chromatography and hyphenated techniques for polymers focused on providing more insight into product performance and process optimization that make easier
The Polymer Market consists of a huge diversity of manufacturers of industrial products running many different processes yet still facing similar challenges. There is more and more pressure to achieve high product quality and reduce costs in order to stay one step ahead of the competition.
With the new TurboMatrix MultiPrep+ and TurboMatrix MultiPrep autosamplers, PerkinElmer offers more choices than ever before to help you optimize the workflow of your gas chromatography instrument and maximize the throughput of your lab.
Based on EPA modeling, Method EPA 325 A/B will lead to a reduction of an estimated 52,000 tons per year of volatile organic compounds being emitted into the environment. In the face of this major new environmental standard, we can all breathe a bit easier knowing that PerkinElmer’s innovative technologies, operational effectiveness, and environmental expertise is available to help you become compliant.
This white paper discusses the role of System Suitability Tests (SSTs) in the context of Analytical Instrument Qualification (AIQ) and is based upon; the United States Pharmacopoeia (USP) general chapter 1058 on AIQ.