Citric acid, labeled with C-14 at C1 and C5. 14C-citrate is commonly used to label long-chain fatty acids.
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ATP citrate lyase (ACL) is a cytosolic enzyme that catalyzes the synthesis of acetyl-CoA and oxaloacetate using citrate, CoA, and ATP as substrates and Mg2+ as a necessary cofactor. The ACL-dependent synthesis of acetyl-CoA is thought to be an essential step for the de novo synthesis of fatty acids and cholesterol. For this reason, inhibition of ACL has been pursued as a strategy to treat dyslipidemia and obesity.
| Concentration | 0.05 mCi/mL |
|---|---|
| Detection Method | Radiometric |
| Label Position | Specifically Labeled |
| Molecular Weight | 192.12 |
| Product Brand Name | NEN Radiochemicals |
| Radioisotope | C-14 |
| Radionuclide | 14C |
| Shipping Condition | Blue Ice |
| Special Ordering Information | This is a radioactive product - shipping address must have a license to receive radioactive materials. |
| Unit Size | 250 µCi |
This document contains general information designed to provide a basic understanding of radiation safety. While we believe the information to be accurate, regulatory requirements may change and information contained herein is not tailored to individual needs.
This document contains general information designed to provide a basic understanding of radiation safety. While we believe the information to be accurate, regulatory requirements may change and information contained herein is not tailored to individual needs.
