Cat K 680 FAST™ is a member of a family of activatable fluorescent imaging agents comprising a novel architecture, termed F.A.S.T. (Fluorescent Activatable Sensor Technology), that confers an improved pharmacokinetic profile with earlier imaging time points. This architecture offers higher target specific signal with reduced background while also reducing the optimal imaging time after injection.
Cat K 680 FAST is a Cathepsin K (Cat K) activatable fluorescent agent that is optically silent upon injection and produces fluorescent signal after cleavage by disease related Cathepsin K. Cat K is highly expressed in osteoclasts, suggesting a specialized role in bone resorption.
Cat K is found extracellularly along the bone and cartilage and intracellularly in lysozomes of osteoclasts attached to the bone. In addition to expression by osteoclasts, Cat K is also expressed by a broad range of other cell types including ovarian cells, colonic tissue, alveolar and bronchial epithelial cells, synovial fibroblasts, breast cancer cells, macrophages.
Disclaimer: For laboratory use only. This product is intended for animal research only and not for use in humans.
|Fluorescent Agent Type||Activatable|
|Optical Imaging Classification||Fluorescence Imaging|
|Product Brand Name||Cat K FAST|
|Quantity in a Package Amount||1.0 Units|
|Therapeutic Area||Atherosclerosis, Arthritis|
|Unit Size||1 Vial (10 doses)|
|Wave Length||680 nm|
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|Resource Type||File Name||File Format|
|Brochure||In Vivo Imaging Agents Brochure||PDF 2 MB|
|Application Note||In Vivo Imaging of Atherosclerosis Disease Using FMT||PDF 1 MB|
|Technical Note||Cat K 680 FAST (Data Sheet)||PDF 153 KB|
|Technical Note||Cat K 680 FAST (Protocol)||PDF 257 KB|
|Poster||Development of a Fast Activating New Near Infrared-Labeled Agent for Detecting||PDF 672 KB|
|Poster||Imaging of Cathepsin K activity in rodent models of bone turnover and soft tissue calcification||PDF 966 KB|
|Poster||MicroCT/optical imaging sorafenib-driven increases in bone loss and inflammation in breast cancer||PDF 1 MB|
|Citations Library||View peer reviewed publications using PerkinElmer's In Vivo Imaging Reagents||Link|
|Webinars||View our complete list of in vivo webinars available on demand||Link|