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Bradykinin, [2,3-Prolyl-3,4-3H(N)]-, 250µCi (9.25MBq)

Bradykinin, tritiated at the 2,3-prolyl-3,4 position. Bradykinin is the endogenous ligand that activates bradykinin B1 and B2 receptors.

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NET706050UC
50 µCi
1759.00 USD
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NET706250UC
250 µCi
4016.00 USD
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Detail Information

Bradykinin binds bradykinin B1 and B2 receptors. Bradykinin receptors are GPCRs involved in inflammation, and are potential drug targets for cancer and inflammatory disease.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET706:

  1. Bellucci, F., Cucchi, P., Catalani, C., Giuliani, S., Meini, S. and Maggi, C. (2009), Novel effects mediated by bradykinin and pharmacological characterization of bradykinin B2 receptor antagonism in human synovial fibroblasts. British Journal of Pharmacology, 158: 1996–2004.
  2. Meini, S., Cucchi, P., Tinti, L. et al. Fasitibant prevents the bradykinin and interleukin 1β synergism on prostaglandin E2 release and cyclooxygenase 2 expression in human fibroblast-like synoviocytes. Naunyn-Schmiedeberg's Arch Pharmacol (2012) 385: 777.

Specifications

Detection Method Radiometric
Label Position Nominally Labeled
Molecular Weight 1060.24
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Bradykinin
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area Angiogenesis, Pain, Cardiovascular, Inflammation
Unit Size 250 µCi
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Radiometric Reagents Guide 2010-2011

For over 50 years PerkinElmer has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed today.

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