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Ascorbic Acid, L-[1-14C]-,>97%, 50µCi (1.85MBq)

L-Ascorbic acid (reduced form of vitamin C; ascorbate), labeled with C-14 at the 1- position. L-ascorbic acid is a vitamin that binds and is transported through sodium-dependent vitamin C transporters (SVCT1 and SCVT2).

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Detail Information

L-ascorbic acid is an essential nutrient involved in the repair of tissue and and regulates neurotransmitter synthesis in the brain. Ascorbic acid and sodium-dependent vitamin C transporters (SVCT) have been shown to have important functions in the peripheral nervous system (PNS). SVCT1 and SVCT2 import the reduced form of ascorbate across plasma membranes.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEC146:

  1. Jin Hyang Song, Seon Ho Shin & Ill Min Chung, Effects of glutamate on dehydroascorbate uptake and Its enhanced vulnerability to the peroxidation in cerebral cortical slices, Experimental and Molecular Medicine, Volume 34, 2002, Pages 419-425.

Specifications

Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 176.1
Product Brand Name NEN Radiochemicals
Radioisotope C-14
Radionuclide 14C
Receptor Type SVCT1, SVCT2
Shipping Condition Ambient
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area Metabolic Disorders
Unit Size 50 µCi
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Guide

Carbon-14 Handling Precautions

This document contains general information designed to provide a basic understanding of radiation safety. While we believe the information to be accurate, regulatory requirements may change and information contained herein is not tailored to individual needs.

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