PerkinElmer
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Transthyretin (human) AlphaLISA Detection Kit, 100 assay points

The AlphaLISA® immunoassay kit for human transthyretin enables the quantitative determination of human transthyretin (TTR) in buffer, serum, cell culture media, and cell lysates using a homogeneous AlphaLISA assay (no wash steps).

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For research use only. Not for use in diagnostic procedures.

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Unit Size
List Price
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AL3111HV
100 Assay Points
782.00 USD
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AL3111C
500 Assay Points
2213.00 USD
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AL3111F
5,000 Assay Points
11100.00 USD
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Detail Information

Formats:

  • Our 100 assay point kit allows you to run 100 wells in 96-well format, using a 100 µL reaction volume (10 µL of sample).
  • Our 500 assay point kit allows you to run 500 wells in 96-well or 384-well format, using a 50 µL reaction volume (5 µL of sample).
  • Our 5,000 assay point kit allows you to run 5,000 wells in 96-well or 384-well format, using a 50 µL reaction volume (5 µL of sample).

AlphaLISA features:

  • No-wash steps, no separation steps
  • ELISA alternative technology
  • Sensitive detection
  • Broad sample compatibility
  • Small sample volume
  • Results in less than 3 hours
  • Half the time of an ELISA assay

AlphaLISA technology allows the detection of molecules of interest in buffer, cell culture media, serum and plasma in a highly sensitive, quantitative, reproducible and user-friendly mode. In an AlphaLISA assay, a Biotinylated Anti-Analyte Antibody binds to the Streptavidin-coated Alpha Donor beads, while another Anti-Analyte Antibody is conjugated to AlphaLISA Acceptor beads. In the presence of the analyte, the beads come into close proximity. The excitation of the Donor beads provokes the release of singlet oxygen molecules that triggers a cascade of energy transfer in the Acceptor beads, resulting in a sharp peak of light emission at 615 nm.

Transthyretin (TTR) is a transport protein in serum and CSF, most notably know for transporting thyroxine (T4) and retinol binding protein. TTR is produced in the liver where it is secreted into the blood. CSF TTR is produced in the choroid plexus. Misfolding and aggregation of TTR has be linked to amyloid diseases. Drugs have been designed to stabilize TTR and prevent mis aggregation.

Specifications

Assay Target Transthyretin
Assay Target Class Protein
Automation Compatible Yes
Detection Method Alpha
Shipping Condition Blue Ice
Unit Size 100 Assay Points
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Brochure

Alpha Technology Solutions

Product brochure for the Alpha Technology, a versatile, no wash, homogeneous assay technology that's suitable for a broad range of applications.

PDF 4 MB

Manual

Protocol for AlphaLISA human transthyretin (TTR) assay

This manual describes how to run the AlphaLISA human transthyretin assay kit.

PDF 601 KB