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α-MSH, Nle4, D-Phe7, [125I], 10µCi

α-Melanocyte-stimulating hormone (α-MSH), labeled with 125I. α-MSH is an endogenous hormone that acts as a non-selective full agonist of melanocortin receptors MC1, MC3, MC4, and MC5.

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Part Number Unit Size List Price Your Price Quantity
NEX352010UC 10 µCi 1036.00 USD
NEX352050UC 50 µCi 2324.00 USD
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We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX352:

  1. Conde-Frieboes, K., Thøgersen, H., Lau, J.F., Sensfuss, U., Hansen, T.K., Christensen, L., Spetzler, J., Olsen, H.B., Nilsson, C., Raun, K., Dahl, K., Hansen, B.S., Wulff, B.S. (2012), Identification and in vivo and in vitro characterization of long acting and melanocortin 4 receptor (MC4-R) selective α-melanocyte-stimulating hormone (α-MSH) analogues. J Med Chem, 55 (5): 1969-1977.
  2. Vagner, J., Handl, H.L., Gillies, R.J., Hruby, V.J. (2004), Novel targeting strategy based on multimeric ligands for drug delivery and molecular imaging: homooligomers of alpha-MSH. Bioorg Med Chem Lett, 14 (1): 211-215.


Detection Method Radiometric
Fresh Lot Days Third Monday of each month
Label Position Nominally Labeled
Product Brand Name NEN Radiolabeled Ligands
Radioisotope I-125
Radionuclide 125I
Receptor Type Melanocortin
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Pain, Inflammation, Metabolic Disorders
Unit Size 10 µCi

Resources, Events & More

Resource Type File Name File Format
Technical Note Low Volume Handling Suggestions for Iodine-125 Labeled Compounds PDF  177 KB
Flyer Using the NENSure Packaging System from PerkinElmer PDF  447 KB