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Adenosine 3',5'-cyclic Phosphoric Acid, 2`-O-succinyl [125I]-Iodotyrosine Methyl Ester-, 50µCi

cAMP, labeled with 125I on the tyrosine methyl ester group. I-125 labeled cAMP can be used as a tracer for radioimmunoassays to detect levels of endogenous cAMP in a sample or for GPCR functional assays.

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Part Number Unit Size List Price Your Price Quantity
NEX130001UC 1 µCi 379.00 USD
NEX130005UC 5 µCi 1203.00 USD
NEX130050UC 50 µCi 4624.00 USD
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Overview

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX130:

  1. Ji H. (2001) Measurement of Cyclic AMP and Cyclic GMP in Xenopus Oocytes Stimulated with Angiotensin II and Atrial Natriuretic Factor. In: Wang D.H. (eds) Angiotensin Protocols. Methods in Molecular Medicine™, vol 51. Humana Press.
  2. Zeytin, F.N., Delellis, R. (1987), The Neuropeptide-Synthesizing Rat 44-2C Cell Line:Regulation of Peptide Synthesis, Secretion, 3,′5′-Cyclic Adenosine Monophosphate Efflux, and Adenylate Cyclase Activation, Endocrinology, 121 (1): 352–360.
  3. Zeytin, F.N., Reyl-Desmars, F., Rathbun, T., (1985), Rat hypothalamic GRF elicits its biologic action in GH3 cells by interaction with VIP-preferring receptor site(S), Biochemical and Biophysical Research Communications, 127 (3): 992-998.

Specifications

Detection Method Radiometric
Fresh Lot Days First Monday of each month
Label Position Specifically Labeled
Product Brand Name NEN Radiolabeled Ligands
Radioisotope I-125
Radionuclide 125I
Shipping Condition Ambient
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Metabolic Disorders
Unit Size 50 µCi

Resources, Events & More

Resource Type File Name File Format
Technical Note Low Volume Handling Suggestions for Iodine-125 Labeled Compounds PDF  177 KB
Flyer Using the NENSure Packaging System from PerkinElmer PDF  447 KB