Dihydroxyphenylethylamine (dopamine) radioligand tritiated at the 2,5,6,7,8 position. Dopamine functions as a neurotransmitter that binds dopamine receptors.
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Dihydroxyphenylethylamine is the natural agonist of dopamine receptors. These receptors are part of a group of G-protein coupled receptors (GPCRs) found in the central nervous system that play a role in motivation, pleasure, cognition, memory, learning, and fine motor control. Dopamine receptors are potential targets for attention deficit hyperactivity disorder (ADHD), schizophrenia, and hypertension.
We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.
Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
|Label Position||Specifically Labeled|
|Product Brand Name||NEN Radiochemicals|
|Shipping Condition||Blue Ice|
|Special Ordering Information||This is a radioactive product - shipping address must have a license to receive radioactive materials.|
|Therapeutic Area||CNS & Neurologic|
|Unit Size||1 mCi|