PerkinElmer

Receptor Ligand Binding

OF

A receptor ligand binding assay allows for the study and simple imaging of cell surface receptors for research and diagnostic applications. Receptor ligand binding is used in drug development applications to identify blocking antibodies or inhibitors that can modulate downstream signaling events, and is often used to screen for drugs that target hormone and neurotransmitter activity. We offer a range of tools for receptor ligand binding assays including radioligands, receptor-transfected cell membranes, and cell lines. Products available support both agonist and antagonist assays.

Our offerings include assays for:

  • Tyrosine kinase receptors
  • G-protein coupled receptors (GPCR)
  • Drug discovery and development
  • Ion channels
  • Protein analysis, detection, and interaction

Our collection of receptor ligand binding related assays includes fluorescence, LANCE® and DELFIA® time-resolved fluorescence, Alpha chemiluminescent assays, lites luminescence assays, and radiometric detection methods. Simplify the development of your assays and the calculation of your results using our radioligands, receptor-transfected cell membranes, and cell lines for receptor ligand binding applications.

  • Products and Services

  • Resources, Events & More

Narrow your results
Product Type
  • Consumables (2)
  • Instruments (7)
  • Reagents (539)
Application
  • cAMP (26)
  • Drug Discovery & Development (338)
  • Mobility Shift (36)
  • Molecular Biology (2)
  • Plant Sciences (1)
  • Protein Analysis & Detection (5)
  • Protein-protein interactions (4)
  • Radiometric (4)
Assay points(200-50,000)
  • 500 (2)
  • 5000 (2)
Assay Target Class
  • GPCR (179)
  • Ion channel (2)
  • Transporter (6)
  • Tyrosine Kinase Receptor (1)
Assay Validated
  • Binding (211)
  • Calcium Fluorescence (20)
  • Calcium Luminescence (2)
  • cAMP (56)
  • Downstream Phosphorylation (1)
  • GTPγS (54)
  • Inositol Phosphate (15)
Automation Compatible
  • No (20)
  • Yes (41)
Coating Treatment
  • Anti-mouse antibody (2)
  • Anti-mouse IgG (2)
  • Anti-rabbit antibody (2)
  • Anti-rabbit IgG (2)
  • Copper (HIS-tag) (2)
  • Copper chelate (2)
  • Glutathione (4)
  • HIS (2)
  • Nickel chelate (HIS-tag) (2)
  • PDE (2)
  • PEI (14)
  • Poly-L-lysine (2)
  • Poly-lysine (5)
  • Protein A (2)
  • RNA Binding (1)
  • Streptavidin (13)
  • Uncoated (1)
  • WGA (17)
  • WGA PEI type A (1)
  • WGA PEI Type B (1)
Color
  • White (4)
Concentration
  • 1 mCi/mL (4)
  • 1.0 - 10 mCi/mL (62)
  • 1.0 - 10 µCi/mL (3)
  • 1.0 mCi/mL (1)
  • 1.12 mCi/mL (1)
  • 1.14 mCi/mL (1)
  • 152 µCi/mL (1)
  • 170.1 µCi/mL (1)
  • 171 µCi/mL (1)
  • 172.5 µCi/mL (1)
  • 173.9 µCi/mL (1)
  • 182 µCi/mL (2)
  • 2 mCi/mL (1)
  • 2.93 MBq/mL (1)
  • 236 µCi (1)
  • 3.06 MBq/mL (1)
  • 3.22 MBq/mL (1)
  • 33.7 µCi (1)
  • 345 µCi/mL (3)
  • 353 µCi/mL (3)
  • 41.4 µCi/mL (2)
  • 42.5 µCi/mL (1)
  • 45.7 µCi/mL (1)
  • 50 µCi/mL (1)
  • 6.05 MBq/mL (1)
  • 79.2 µCi/mL (2)
  • 83.8 µCi/mL (1)
  • 85.1 µCi/mL (1)
  • 87.2 µCi/mL (1)
  • 87.4 µCi/mL (1)
  • 87.6 µCi/mL (1)
  • 87.9 µCi/mL (1)
  • 88.5 µCi/mL (1)
  • 93.2 µCi/mL (1)
  • <1.0 mCi/mL (7)
  • <1.0 µCi/mL (3)
  • <100 µCi/mL (1)
Detection Method
  • Alpha (3)
  • DELFIA TRF (4)
  • Filtration (4)
  • Fluorescence (1)
  • Radiometric (257)
  • Time-Resolved Fluorescence (TRF) (4)
Experimental Type
  • In vitro (4)
Fluorophore
  • Eu-N1-ITC (2)
Format
  • Microplates (19)
  • Tubes (11)
Host Cell
  • 1321N1 (12)
  • A431 (1)
  • A9 (1)
  • CHO-DHFR(-) (1)
  • CHO-K1 (132)
  • HEK293 (38)
  • HT29 (1)
  • K562 (1)
  • L Cells (1)
  • MDA-MB-435S (1)
  • MDCK (2)
  • U373 (1)
  • UC11 (1)
Label Position
  • Generally Labeled (6)
  • Nominally Labeled (98)
  • Specifically Labeled (97)
  • Uniformly Labeled (1)
Material
  • Barex/GF/B (1)
  • Barex/GF/C (1)
  • Polystyrene/GF/B (1)
  • Polystyrene/GF/C (1)
Number of Wells
  • 96 (4)
Product Brand Name
  • AequoZen (2)
  • AlphaLISA (3)
  • cAMPZen (1)
  • DELFIA (4)
  • LabChip EZ Reader (50)
  • Membrane Target Systems (114)
  • MicroBeta (2)
  • NEN Radiochemicals (121)
  • NEN Radiolabeled Ligands (76)
  • OmniFilter (1)
  • SPA Imaging Beads (18)
  • SPA Scintillation Beads (26)
  • UniFilter (7)
  • ValiScreen (75)
Radionuclide
  • 125I (78)
  • 14C (5)
  • 33P (2)
  • 35S (1)
  • 3H (1)
  • 3H (114)
Radioisotope
  • C-14 (6)
  • H-3 (115)
  • I-125 (78)
  • P-33 (2)
  • S-35 (1)
Receptor Type
  • 5-Hydroxytryptamine (12)
  • 5-Hydroxytryptamine (Serotonin) (23)
  • Acetylcholine (1)
  • Acetylcholine (Muscarinic) (16)
  • Adenosine (14)
  • Adrenergic (13)
  • Adrenoceptors (11)
  • Anaphylatoxin (4)
  • Angiotensin (9)
  • Apelin (2)
  • Benzodiazepine (6)
  • Bombesin (5)
  • Bradykinin (3)
  • Calcitonin (6)
  • Calcium (6)
  • Cannabinoid (8)
  • Chemokine (15)
  • Cholecystokinin (5)
  • Corticotropin-Releasing Factor (1)
  • Dopamine (20)
  • Dopamine Transporter (2)
  • Endothelin (3)
  • Epidermal Growth Factor (2)
  • Formyl Peptide (2)
  • Free Fatty Acid (2)
  • GABA (4)
  • GABAA (6)
  • GABAB (1)
  • Galanin (5)
  • Ghrelin (4)
  • Glucagon (7)
  • Glutamate (7)
  • Glycine (4)
  • Gonadotropin-releasing Hormone (1)
  • Growth Hormone (1)
  • hERG (3)
  • Histamine (10)
  • Insulin (3)
  • Insulin-like Growth Factor (1)
  • Interleukin (1)
  • Leukotriene (3)
  • Melanin-Concentrating Hormone (1)
  • Melanocortin (13)
  • Melatonin (2)
  • Metastin (1)
  • Motilin (1)
  • Muscarinic (10)
  • Neuromedin U (3)
  • Neuropeptide (7)
  • Neuropeptide Y (3)
  • Neurotensin (6)
  • Nicotinic (8)
  • NMDA (1)
  • Norephinephrine (1)
  • Norepinephrine (2)
  • Opioid (19)
  • Orexin (2)
  • Oxytocin (2)
  • Peptide P518 (1)
  • Platelet-Derived Growth Factor (1)
  • Potassium (2)
  • Progestin (1)
  • Prokineticin (1)
  • Prolactin Releasing Peptide (2)
  • Prostanoid (9)
  • Purinergic P2Y (2)
  • Relaxin (3)
  • Retinoic Acid Receptors (1)
  • Serotonin (5)
  • SK channels (1)
  • Sodium (1)
  • Somatostatin (11)
  • SVCT1 (1)
  • SVCT2 (1)
  • Tachykinin (7)
  • Thyroid Hormone (3)
  • Thyrotropin Releasing Hormone (1)
  • Thyrotropin-releasing Hormone (2)
  • Transforming Growth Factor (1)
  • TRPC5 (1)
  • Urotensin (2)
  • Vasoactive Intestinal Peptide (3)
  • Vasopressin (12)
  • Vesicular Amine Transporters (VATs) (1)
Sample Type
  • Enzyme (38)
Target Species
  • Human (8)
Therapeutic Area
  • Angiogenesis (27)
  • Biologics/Bioprocess (2)
  • Cancer (22)
  • Cardiovascular (119)
  • Central Nervous System (97)
  • CNS & Neurologic (126)
  • Diabetes (20)
  • Gastrointestinal (77)
  • Immune (3)
  • Inflammation (139)
  • Metabolic (53)
  • Metabolic Disorders (43)
  • Musculoskeletal (1)
  • Obesity (9)
  • Pain (72)
  • Parasympathetic Nervous System (5)
  • Renal (2)
  • Sympathetic Nervous System (2)
Volume
  • 0-50 (47)
  • 51-100 (2)
  • 201-250 (60)

"Receptor Ligand Binding" 1-50 of 548 Products and Services

Sort
Per Page

MICROBETA FILTERMAT-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use. Need additional information? Click on the tabs in the product details section below.

UNIFILTER-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.

UNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.

UNIFILTER-96 CELL HARVESTER SS

Speed and simplicity are the primary strengths of the Unifilter Harvester.

MICROBETA FILTERMAT-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use.
LabChip EZ Reader

EZ READER, SHIP LEVEL

The EZ Reader can help to save time and money in your laboratory by identifying the most promising lead candidates faster.

The EZ Reader instrument is available outside the EU. Please contact your local representative for further information.

OMNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the OmniFilter Harvester.
Receptor-expressing cell lines

ValiScreen Galanin Gal1 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

Somatostatin-14 (human, recombinant), [125I], Receptor Grade

NEX446 Tyr11 Somatostatin-14 is radioiodinated with no-carrier-added 125I using amodified lactoperoxidase procedure and is purified by reversed phase HPLC. This method predominantly labels tyrosine residues.
Price Range : 945.00 USD - 2291.00 USD

Ifenprodil, [Phenyl-3H]-, 250µCi (9.25MBq)

Ifenprodil, tritiated on the phenyl group. Ifenprodil acts as an antagonist at the N-methyl-D-aspartate (NMDA) receptor.
List Price : 1990.00 USD
PerkinElmer

Membrane Target Systems: Neuropeptide NPFF1 (human) membrane preparation in CHO-K1 cells

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD

GLP-1 (7-36), [125I]

Glucagon-like peptide-1 (GLP-1), labeled with 125I. GLP-1 is a peptide hormone involved in secretion of insulin, and binds and activates GLP-1 receptors, a member of the glucagon receptor family of GPCRs.
Price Range : 1219.00 USD - 2224.00 USD

N-succinimidyl-3-(4-hydroxy-3-[125I]iodophenyl)propionate, Bolton-Hunter Reagent

Bolton-Hunter reagent, monoiodinated. This product is used to iodinate proteins that do not contain tyrosine residues. Bolton-Hunter reagent is the N-hydroxysuccinimide ester of iodinated p-hydroxyphenylpropionic acid. The active ester acylates terminal amino groups with the iodinated p-hydxyphenylpropionic residue, effectively introducing radioactive iodine into proteins and peptides. A non-oxidative technique, it is less harsh to proteins than alternative labeling methods. An anhydrous benzene A charcoal trap is provided with each vial.
Price Range : 582.00 USD - 1589.00 USD
PerkinElmer

Membrane Target Systems: Melanocortin MC5 (mouse) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD
Receptor-expressing cell lines

Opioid Mu (OP3) (human) ValiScreen cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

Acetylcholine Iodide, [acetyl-3H], 1mCi (37MBq)

Acetylcholine (Ach) radioligand tritiated on the acetyl group. Acetylcholine is a neurotransmitter and the endogeous ligand that binds to and activates muscarinic and nicotinic acetylcholine receptors.
List Price : 1411.00 USD

Vasopressin (Linear), V-1A Antagonist (Phenylacetyl1, 0-Me-D-Tyr2, [125I-Arg6]-)

Vasopressin (linear), labeled with 125I. Linear vasopressin acts as an antagonist at vasopressin receptor 1A (V1AR).
Price Range : 964.00 USD - 2140.00 USD
PerkinElmer

Membrane Target Systems: Leukotriene CysLT1 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD
Receptor-expressing cell lines

ValiScreen Histamine H1 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

R(+)7-HYDROXY DPAT, [3H], 250 µCi

Tritiated R(+)7-Hydroxy DPAT. 7-OH-DPAT acts as a selective agonist at the dopamine D3 receptor. It also has low affinity for serotonin receptors.
List Price : 3292.00 USD
PerkinElmer

Membrane Target Systems: Opioid Mu (OP3) (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD

GR113808,[N-methyl-3H]-

GR113808, tritiated on the N-methyl group. GR113808 acts as a selective antagonist at the 5-HT4 receptor.
List Price : 4070.00 USD

GR 65630, [N-Methyl-3H]

GR 65630, tritiated on the N-methyl group. GR 65630 acts as a selective antagonist at the 5-HT3 receptor.
Price Range : 642.00 USD - 3119.00 USD
Receptor-expressing cell lines

ValiScreen Somatostatin sst2a (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

WGA-PEI TYPE A PS 500 MG

WGA-coated SPA beads, for capturing cell membranes in proximity-based scintillation assays.
List Price : 582.00 USD

Serine, D-[3H(G)]-, 250µCi (9.25MBq)

Tritiated D-Serine. D-Serine acts as an agonist at N-methyl-D-aspartate receptors (NMDA receptors).
List Price : 1981.00 USD
PerkinElmer

Glutathione PVT 2G

Glutathione-coated SPA beads, for capturing GST-tagged proteins in proximity-based radiometric scintillation assays.
List Price : 2216.00 USD
Receptor-expressing cell lines

ValiScreen Galanin Gal2 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

(+)-Pentazocine, [Ring-1,3-3H]

(+)-Pentazocine radioligand tritiated at the 1,3 position on the ring. Pentazocine is a synthetic opioid shown to bind sigma 1 receptor.
Price Range : 621.00 USD - 4846.00 USD

Sauvagine, [125I]-Tyr0]

Sauvagine, labeled with 125I on the tyrosine 0 residue. Sauvagine is a neuropeptide that acts as an agonist at corticotropin-releasing factor receptors (CRF receptors) 1 and 2.
Price Range : 1041.00 USD - 2164.00 USD

Bradykinin, [2,3-Prolyl-3,4-3H(N)]

Bradykinin, tritiated at the 2,3-prolyl-3,4 position. Bradykinin is the endogenous ligand that activates bradykinin B1 and B2 receptors.
Price Range : 1759.00 USD - 4016.00 USD

DAMGO, [Tyrosyl-3,5-3H(N)]

DAMGO, tritiated at the tyrosyl 3,5 poisition. DAMGO is a synthetic opioid analog with high specificity for the μ-opioid receptor.
Price Range : 1720.00 USD - 4448.00 USD
PerkinElmer

Glutathione coupled Yttrium Oxide Imaging Particles

Glutathione-coated SPA beads, for capturing GST-tagged proteins in proximity-based scintillation assays.
List Price : 851.00 USD

Hemicholinium-3 Diacetate Salt, [Methyl-3H]-, 250µCi (9.25MBq)

Hemicholinium-3 (HC3; hemicholine) Diacetate Salt, tritiated on the methyl group. Hemicholinium-3 blocks reuptake of choline by the high-affinity choline transporter.
List Price : 3220.00 USD
PerkinElmer

Membrane Target Systems: Prostanoid CRTH2 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD
Receptor-expressing cell lines

ValiScreen Somatostatin sst4 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

SDF-1α (human, recombinant), [125I]

Stromal cell-derived factor 1 alpha (SDF-1α; CXCL12), labeled with 125I. SDF-1α binds the CXCR4 receptor.
Price Range : 744.00 USD - 1999.00 USD

Gastric Inhibitory Polypeptide (human), [125I]

Gastric inhibitor polypeptide (GIP), labeled with 125I. GIP is a hormone that binds receptors found on beta cells in the pancreas.
Price Range : 943.00 USD - 1808.00 USD

INSULIN (porcine), [125I], 10µCi (370kBq), Specific Activity:80-120µCi (2.96-4.44MBq)/µg

Insulin (porcine), labeled with 125I. Insulin is a peptide hormone that binds to insulin receptors to increase cellular uptake of glucose, increase DNA replication and protein synthesis, and modify enzymatic activity. This product is radioiodinated with 125I using a modification of the Hunter and Greenwood method and purified by ion-exchange column chromatography. This method predominantly labels tyrosine residues.
List Price : 833.00 USD

RX 821002, [6,7-3H(N)]-

RX 821002, tritiated at the 6,7 position. RX 821002 acts as an antagonist at α2-adrenoceptors.
List Price : 2048.00 USD

Ro 15-1788, [N-Methyl-3H]

Ro 15-1788 (flumazenil), tritiated on the N-methyl group. Ro 15-1788 acts as a selective benzodiazepine antagonist.
Price Range : 648.00 USD - 4858.00 USD
Receptor-expressing cell lines

ValiScreen Glucagon - R (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

Membrane Target Systems: Serotonin 5HT-2A (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD

Neurotensin, [3,11-Tyrosyl-3,5-3H(N)]

Neurotensin radioligand tritiated at the 3,5 position of the tyrosine residues. Neurotensin is a neuropeptide that acts as an agonist on the neurotensin receptor family.
Price Range : 664.00 USD - 3490.00 USD
Receptor-expressing cell lines

Dopamine D1 (human) ValiScreen® cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

Membrane Target Systems: Histamine H1 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD
Receptor-expressing cell lines

ValiScreen Chemotactic Peptide C3a (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

Deltorphin II (2-D-Ala), [Tyrosyl-3,5-3H]

Deltorphin II, tritiated at the tyrosyl-3,5 position. Deltorphin II is a selective δ opioid receptor (DOPR) agonist.
Price Range : 913.00 USD - 3866.00 USD
PerkinElmer

Membrane Target Systems: Galanin Gal2 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD

"Receptor Ligand Binding" 1-50 of 548 Products and Services

Per Page