Radiometric detection is considered the gold standard for many applications, from drug discovery and development to plant sciences. The technique achieves sub-femtogram sensitivity levels, and quantitates the binding and activity of radiolabeled compounds with high specificity and sensitivity. As the leading supplier of research radiochemicals, we offer a broad portfolio of products for any radiochemistry need.
Our radiochemical analysis products include:
Radionuclides such as 124I, 14C, 89Zr, 90Y, 125I, 131I, 22Na, 32P, 35S, 3H, 45Ca, 51Cr, 54Mn, 55Fe, 59Fe, 85Sr
EasyTag™ protein labeling mixes
EasyTide radiolabeled nucleotides
NEN radiolabeled compounds
SPA Enzymatic assays and imaging beads
Our radiolabeled compounds are useful in a wide range of applications:
Research in cancer, CNS and neurologic disease, cardiovascular and metabolic disease, inflammation, and other disorders
Kinetic and mechanistic studies
Radiometric cAMP assays
Detection of binding to over 80 different receptor types
Our radiometric reagents are not reliant on the use of antibodies for detection and read-out – just one of the reasons they are so widely used.
Human recombinant macrophage inflammatory protein 1-alpha (MIP-1α; CCL3), labeled with 125I. MIP-1α is a cytokine involved in acute inflammation, and binds C-C chemokine receptors CCR1, CCR4, and CCR5.
Glucagon-like peptide-1 (GLP-1), labeled with 125I. GLP-1 is a peptide hormone involved in secretion of insulin, and binds and activates GLP-1 receptors, a member of the glucagon receptor family of GPCRs.
2-Deoxy-D-glucose, nominally labeled with tritium at C1/C2. This product is supplied steri-packaged in an aqueous solution. Deoxy-D-glucose (DOG) is a glucose analog that is readily transported into most cells, is phosphorylated and trapped by the cells (unidirectional transport), and cannot be further metabolized. It is the most-common chemical used in glucose uptake assays.
D-aldosterone, tritiated at C1,C2,C6,C7. 3H-aldosterone is commonly used in mineralocorticoid (aldosterone) receptor binding studies. This product will have scheduled availability dates on the first Monday in June and December.