PerkinElmer

Protein-protein Interaction Research

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Protein-protein interaction research is uncovering new targets for drug discovery in cancer and a variety of other diseases. However, measurement, modulation, and detection of protein-protein interaction is challenging, and requires technology capable of measuring both high- and low-affinity interactions.

The full measurement capabilities of our protein-protein interaction analysis technologies include:

  • Transient and stable interactions
  • Low-to-high affinity interactions (pM to mM affinity)
  • Full-length protein-protein binding
  • Peptide-protein
  • Receptor dimerization
  • Protein-small molecule
  • Protein complex interactions

Modulation of protein interactions can affect signal transduction, growth factor, gene expression, and other factors, making it a promising new avenue for protein-based treatment.

Development of protein-based therapeutics requires a thorough understanding of protein function and interactions. Our protein-protein interaction assays and instruments allow fast, multilabel detection of protein-protein interaction for drug discovery.

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  • Accessories (4)
  • Instruments (6)
  • Reagents (109)
Antibody Conjugates
  • Anti-6X His (7)
  • Anti-bovine IgA (1)
  • Anti-c-Myc (4)
  • Anti-C-tag (3)
  • Anti-DIG (2)
  • Anti-DNP (2)
  • Anti-FITC (3)
  • Anti-FLAG (6)
  • Anti-GFP (2)
  • Anti-goat IgG (1)
  • Anti-GST (5)
  • Anti-HA (4)
  • Anti-HRP (2)
  • Anti-human IgG (3)
  • Anti-MBP (1)
  • Anti-mouse IgG (3)
  • Anti-rabbit IgG (2)
  • Anti-rat IgG (2)
  • Anti-V5 (3)
  • Glutathione (3)
  • Nickel chelate (1)
  • Protein A (5)
  • Protein G (1)
  • Protein L (1)
  • Strep-Tactin (1)
  • Streptavidin (11)
  • Streptavidin/Anti-c-Myc (1)
  • Streptavidin/Anti-DIG (1)
  • Streptavidin/Anti-FITC (1)
  • Streptavidin/Anti-FLAG (1)
  • Streptavidin/Anti-GST (1)
  • Streptavidin/Anti-HA (1)
  • Streptavidin/Anti-mouse IgG (1)
  • Streptavidin/Anti-rabbit IgG (1)
  • Streptavidin/Nickel chelate (1)
  • Streptavidin/Protein A (1)
  • Unconjugated (2)
Application
  • Antibody binding (1)
  • Enzymatic (5)
  • Isotyping (1)
  • Multiplexing (2)
  • Protein Analysis & Detection (51)
  • Protein-nucleic acid interactions (4)
  • Protein-protein interactions (94)
Assay points(200-50,000)
  • 100 (5)
  • 10000 (11)
  • 500 (25)
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  • 50000 (10)
Assay Target
  • COX-2 (2)
  • EGF (2)
  • EGFR (3)
  • FCGR1 (1)
  • FCGR2A (2)
  • FCGR2B (1)
  • FCGR3A (2)
  • Histone H4 (2)
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  • PD-1 (2)
  • PD-L1 (2)
Assay Target Class
  • Fc-receptor (6)
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  • Protein (8)
Automation Compatible
  • Yes (112)
Detection Method
  • Absorbance (5)
  • Alpha (67)
  • DELFIA TRF (7)
  • Fluorescence (5)
  • Fluorescence Polarization (3)
  • Image-based Cytometry (1)
  • Label-free (2)
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  • Time-Resolved Fluorescence (TRF) (31)
  • TR-FRET (19)
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  • In vitro (78)
Fluorophore
  • Eu-N1 (5)
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  • Eu-W8044 (1)
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  • SureLight APC (4)
  • Tb-N1 (1)
  • ULight (8)
Format
  • Microplates (84)
Maximum Temperature (Celsius)
  • 40-50 (2)
  • 50-60 (2)
Molecular Modification
  • Acetylation (2)
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  • Alpha (6)
  • AlphaLISA (42)
  • AlphaPlex (16)
  • AlphaScreen (12)
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  • Victor (1)
  • ViewLux (1)
Target Species
  • Human (9)
  • Mouse (1)
Therapeutic Area
  • Biologics/Bioprocess (6)
  • Cancer (8)
  • Epigenetics (2)

"Protein-protein Interaction Research" 1-50 of 119 Products and Services

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EnSpire Alpha Plate Reader

The EnSpire Alpha Plate Reader provides proven Alpha technology to your lab at an affordable price and from the Alpha detection leader.

EnSpire Plate Reader is available outside the EU. Please contact your local representative for further details.

VictorX_ImageA_320px

VICTOR Multilabel Plate Reader

The VICTOR Multilabel plate reader has been replaced by the VICTOR Nivo multimode plate reader. Please contact your local representative for further information, or visit the VICTOR Nivo product page (Part Number - HH35000500).
EnSight multimode plate-reader

EnSight Multimode Plate Reader

The EnSight multimode plate reader combines labeled & image-based cytometry technologies in a single benchtop platform. Imaging & online data analysis is fast: a 384-well plate can be imaged in less than 5 mins. The system’s modular design, combined with workflow-based Kaleido data acquisition & analysis software, gives a truly versatile plate reader that gets users productive quickly.
EnVision_Alone_Left_Angle

EnVision 2105 Multimode Plate Reader

The EnVision 2105 multimode plate reader provides exceptional speed, ultra-high throughput, and maximum sensitivity across all detection technologies. Tried and tested, the EnVision microplate reader gives you robust performance and reliable data for high throughput screening, time after time.

The EnVision 2105 model delivers even higher sensitivity for time-resolved fluorescence (TRF) applications, and the Enhanced Security software option includes tools to facilitate 21 CFR Part 11 compliance for integration into regulated environments (GxP). In addition, the Alpha 775 laser module is designed for plant assays.

EnSpire Multimode Plate Reader

EnSpire® Multimode Plate Reader is designed to meet the demands of multi-user research environments, providing high performance technology and flexibility for a range of applications without compromising sensitivity. Combine this with our expertise and portfolio of reagents, PerkinElmer offers an unrivaled solution to your application needs.

EnSpire Plate Reader is available outside the EU. Please contact your local representative for further details.

ViewLux uHTS Microplate Imager

The ViewLux® is the gold standard, ultra high-speed microplate imager, ideal for high throughput screening of compound libraries requiring the ultimate in speed, reliability and high quality data.

The ViewLux uHTS microplate imager is available outside the EU. Please contact your local representative to discuss alternative products.

AlphaPlex-545-antibody-bead2

Anti-Mouse IgG AlphaPlex-545 (Tb) Acceptor Beads

AlphaPlex-545 (Terbium) Acceptor beads conjugated to anti-mouse IgG antibody, for use in Alpha no-wash multiplexing assays.
Price Range : 587.00 USD - 24100.00 USD
AlphaPlex Samarium Acceptor Beads

Streptavidin AlphaPlex™ 645 (Sm) Acceptor Beads

The Streptavidin coated AlphaPlex™ 645 (Samarium) Acceptor beads are used to capture a wide variety of biotinylated reagents, ranging from small nucleotides to very large proteins. To avoid steric hindrance, it is recommended to use biotin derivatives including an aliphatic spacer composed of at least six carbons.
Price Range : 587.00 USD - 24100.00 USD
AlphaLISA Binding Assay kits

PD-1/PD-L1 (human) AlphaLISA Binding Kit

The AlphaLISA® PD-1/PD-L1 Binding Kit is designed for the detection of binding activity between Human PD-1 and PD-L1, using a homogeneous AlphaLISA assay (no wash steps). This assay can facilitate the design and development of therapeutics which competitively inhibit PD-1/PD-L1 interaction.
Price Range : 695.00 USD - 9700.00 USD
Alpha_Donor_bead_1

AlphaScreen Streptavidin Donor beads

Alpha Donor beads conjugated to streptavidin.
Price Range : 360.00 USD - 10100.00 USD
AlphaPlex-545-unconjugated

Unconjugated AlphaPlex-545 Acceptor Beads

Unconjugated AlphaPlex 545 (Terbium) Acceptor beads bear reactive aldehyde groups at their surface, allowing you to conjugate a wide variety of reagents using a simple reductive amination protocol.
Price Range : 1343.00 USD - 28300.00 USD
PerkinElmer

LANCE Eu-W1024 Anti-c-Myc

Europium-labeled anti-c-myc antibody, for capturing c-myc-tagged proteins in LANCE® TR-FRET assays.
Price Range : 298.00 USD - 14300.00 USD

AlphaLISA anti-mouse IgG Acceptor beads

AlphaLISA Acceptor beads conjugated to anti-mouse IgG antibody. This antibody is not Fc-specific; for Fc-specific beads, please see product AL105.
Price Range : 565.00 USD - 23200.00 USD
DELFIA; Eu-N1 Rabbit Anti-Mouse-IgG

DELFIA Eu-N1 Streptavidin

DELFIA® Europium-labeled streptavidin, for use in DELFIA time-resolved fluorescence (TRF) assays.
List Price : 380.00 USD
PerkinElmer

LANCE Eu-W1024 Anti-HA

Europium-labeled anti-HA antibody, for capturing HA-tagged proteins and peptides in LANCE® TR-FRET assays.
Price Range : 1043.00 USD - 13900.00 USD
AlphaPlex-545-antibody-bead2

Anti-human IgG AlphaPlex 545 Acceptor Beads

AlphaPlex™-545 (Terbium) Acceptor beads conjugated to anti-human IgG antibody, for use in Alpha no-wash multiplexing assays.
Price Range : 587.00 USD - 24100.00 USD
AlphaLISA immunoassay kits

FCGR3A/CD16a (176Val/V158) AlphaLISA Binding Kit

This kit is designed for the detection of binding activity between human FCGR3A (176Val) and human IgG Fc fragment using a homogeneous AlphaLISA® assay (no wash steps). This assay can facilitate the design and development of antibody therapetics by using competitive binding.
Price Range : 695.00 USD - 10600.00 USD
PerkinElmer

LANCE Eu-W1024 anti-FITC

Eu-W1024 labeled anti-FITC antibodies for LANCE® TR-FRET assays. The anti-FITC antibody is a purified mouse IgG2a monoclonal antibody.
Price Range : 318.00 USD - 8900.00 USD

AlphaScreen FITC (Fluorescein) Detection Kit

AlphaScreen® no-wash assay kit containing Streptavidin Donor beads and Anti-FITC conjugated AlphaScreen Acceptor beads. 
Price Range : 192.00 USD - 13800.00 USD
PerkinElmer

Protein A AlphaPlex™ 545 Acceptor Beads

AlphaPlex™-545 (Terbium) Acceptor beads conjugated to Protein A, for use in Alpha no-wash multiplexing assays.
Price Range : 587.00 USD - 24100.00 USD

Anti-HRP AlphaLISA Acceptor Beads

AlphaLISA® Acceptor beads conjugated to anti-HRP antibody. These beads can be used to capture HRP-fusion proteins for AlphaLISA no-wash assays.
Price Range : 571.00 USD - 23400.00 USD
AlphaPlex-545-antibody-bead2

Anti-rabbit IgG AlphaPlex-545 (Tb) Acceptor Beads

AlphaPlex™-545 (Terbium) Acceptor beads conjugated to anti-rabbit IgG antibody, for use in Alpha no-wash multiplexing assays.
Price Range : 587.00 USD - 24100.00 USD

COX-2 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human COX-2 enables the detection and quantitation of human COX-2 in cell culture supernatants and cell extracts using a homogeneous AlphaLISA assay (no wash steps). The assay shows no cross-reactivity with human COX-1 nor with sheep COX-2.
Price Range : 4224.00 USD - 31200.00 USD

Anti-DNP AlphaLISA Acceptor Beads

AlphaLISA® Acceptor beads conjugated to anti-DNP antibody. These beads can be used to capture DNP-labeled proteins, peptides, and small molecules.
Price Range : 796.00 USD - 18600.00 USD

ULight anti-FITC

ULight™ labeled anti-FITC antibody for LANCE® TR-FRET assays. The anti-FITC antibody is a purified mouse IgG2a monoclonal antibody.
Price Range : 428.00 USD - 10800.00 USD

Anti-bovine IgA AlphaLISA Acceptor Beads

AlphaLISA Acceptor beads conjugated to anti-bovine IgA antibody. These beads can be used to capture bovine IgA antibodies.
Price Range : 797.00 USD - 26900.00 USD

Anti-C-tag AlphaLISA Acceptor Beads

AlphaLISA Acceptor beads conjugated to anti-C-tag antibody. These beads can be used to capture C-tag proteins, and can be used in conjunction with Alpha Donor beads to create AlphaLISA no-wash assays.
Price Range : 588.00 USD - 24100.00 USD
PerkinElmer

LANCE Eu-W1024 anti-FLAG

Eu-W1024 labeled anti-FLAG antibodies for LANCE® TR-FRET assays. The anti-FLAG antibody is a purified mouse IgG2a monoclonal antibody (clone 29E4.G7.H11). The antibody is know to recognize C-terminal and N-terminal FLAG-tagged proteins.
Price Range : 402.00 USD - 9000.00 USD
Alpha donor antibody coated

Anti-DIG Alpha Donor beads

Alpha Donor beads conjugated to anti-DIG (digoxin) antibody. This bead can be used to capture Dig-labeled biomolecules for Alpha no-wash assays.
Price Range : 514.00 USD - 8700.00 USD

AlphaScreen GST Detection Kit

AlphaScreen® no-wash assay kit containing Streptavidin Donor beads and Anti-GST conjugated AlphaScreen Acceptor beads. This kit contains enough reagents to run 500 wells in 384-well format, using a 25 µL reaction volume.
Price Range : 180.00 USD - 13800.00 USD

Streptavidin AlphaLISA® Acceptor beads

AlphaLISA® Acceptor beads conjugated to streptavidin. These beads can be used to capture biotinylated proteins, peptides, nucleic acids (DNA and RNA), and small molecules for AlphaLISA no-wash assays.
Price Range : 588.00 USD - 24100.00 USD
DELFIA; Eu-N1 Rabbit Anti-Mouse-IgG

DELFIA® Eu-N1 Anti-6xHis

Europium-labeled anti-6X His antibody, for capturing His-tagged proteins in DELFIA® TRF assays. The anti-6xHis antibody is a purified mouse IgG1 monoclonal antibody. It is raised against a polypeptide containing a 6x histidine tag. The antibody has been shown to detect polyhistidine tags localized at the amino- or carboxyl-terminus.
Price Range : 465.00 USD - 4338.00 USD

LANCE® Eu-W1024 labeled anti-GST antibody

Europium-labeled anti-GST antibody, for capturing GST-tagged proteins in LANCE® TR-FRET assays.
Price Range : 211.00 USD - 10400.00 USD

Protein G AlphaLISA Acceptor Beads

AlphaLISA® Acceptor beads conjugated to Protein G. These beads can be used to capture antibodies that associate with Protein G.
Price Range : 588.00 USD - 24100.00 USD

Anti-goat IgG (Fc specific) AlphaLISA® Acceptor Beads

AlphaLISA® Acceptor beads conjugated to anti-goat IgG antibody. These beads can be used to capture goat IgG antibodies. The antibody is Fc-specific, and is a rabbit polyclonal F(ab')2 fragment.
Price Range : 588.00 USD - 24100.00 USD
PerkinElmer

SureLight Allophycocyanin-anti-GST antibody, 1 mg, lyophilized

APC-labeled anti-GST antibody, for capturing GST-tagged proteins and peptides in LANCE TR-FRET assays.
List Price : 497.00 USD
AlphaLISA immunoassay kits

FcγR3B (CD16b) AlphaLISA Binding Kit

The AlphaLISA FCGR3B (CD16b) binding kit is designed for the detection of binding between FcγR3B (CD16b) and human IgG Fc fragment using a homogeneous AlphaLISA assay (no wash steps). This assay can facilitate the design and development of antibody therapeutics using a competition assay format.
Price Range : 2122.00 USD - 10600.00 USD
Alpha donor antibody coated

Anti-DNP Alpha Donor Beads

Alpha Donor beads conjugated to anti-DNP antibody. These beads can be used to capture DNP-labeled proteins, peptides, and small molecules.
Price Range : 1591.00 USD - 18600.00 USD

FcγR2A/CD32a (167H) AlphaLISA Binding Kit

This kit is designed for the detection of binding between FCGR2A (CD32a) (167H) and human IgG Fc fragment using a homogeneous AlphaLISA® assay (no wash steps). This assay can facilitate the design and development of antibody therapeutics by using competitive binding.
Price Range : 2123.00 USD - 10600.00 USD
AlphaPlex-545-antibody-bead2

Anti-6X His AlphaPlex-545 (Tb) Acceptor beads

AlphaPlex-545 Acceptor beads conjugated to anti-6XHis antibody, for use in Alpha no-wash multiplexing assays.
Price Range : 587.00 USD - 24100.00 USD

AlphaScreen Mouse IgG Detection Kit

AlphaScreen® no-wash assay kit containing Streptavidin Donor beads and Anti-mouse IgG conjugated AlphaScreen Acceptor beads.
Price Range : 180.00 USD - 13800.00 USD
AlphaPlex Samarium Acceptor Beads

Unconjugated AlphaPlex™ 545 Acceptor Beads

Unconjugated AlphaPlex 645 (Samarium) Acceptor beads bear reactive aldehyde groups at their surface, allowing you to conjugate a wide variety of reagents using a simple reductive amination protocol.
Price Range : 1343.00 USD - 28300.00 USD

Anti-Maltose-Binding Protein (MBP) AlphaLISA® Acceptor beads

AlphaLISA® Acceptor beads conjugated to anti-MBP (maltose-binding protein) antibody. The antibody is a rat monoclonal antibody, clone MBP 7G4. These beads can be used to capture MBP-tagged proteins for AlphaLISA no-wash assays.
Price Range : 588.00 USD - 24100.00 USD
PerkinElmer

SureLight Allophycocyanin-streptavidin (APC-SA), protein binding assay, Iyophilized

APC-labeled streptavidin, for use in LANCE® TR-FRET protein binding assays.
Price Range : 397.00 USD - 11200.00 USD

Strep-Tactin® AlphaLISA® Acceptor beads

AlphaLISA® Acceptor beads conjugated to Strep-Tactin®. These beads can be used to capture Strep-tag® II-tagged proteins for AlphaLISA no-wash assays.
Price Range : 571.00 USD - 23500.00 USD
Alpha donor antibody coated

Anti-rat IgG Alpha Donor Beads

Alpha Donor beads conjugated to anti-rat IgG antibody. This bead can be used to capture rat IgG antibodies for Alpha no-wash protein detection, antibody detection, antibody binding, and other applications.
Price Range : 513.00 USD - 8700.00 USD
PerkinElmer

SureLight Allophycocyanin-anti-6His antibody, 1 mg, lyophilized

APC-labeled anti-His antibody, for capturing His-tagged proteins and peptides in LANCE TR-FRET assays.
List Price : 570.00 USD

Anti-c-myc AlphaLISA® Acceptor Beads

AlphaLISA® Acceptor beads conjugated to anti-c-myc antibody. These beads can be used to capture c-myc-tagged proteins and peptides in AlphaLISA no-wash assays.
Price Range : 588.00 USD - 24100.00 USD

AlphaScreen FLAG (M2) Detection Kit

AlphaScreen® no-wash assay kit containing Streptavidin Donor beads and Anti-FLAG conjugated AlphaScreen Acceptor beads. 
Price Range : 180.00 USD - 13800.00 USD
AlphaPlex Samarium Acceptor Beads

Protein A AlphaPlex™ 645 (Sm) Acceptor Beads

AlphaPlex-645 (Samarium) Acceptor beads conjugated to Protein A. These beads are used to capture immunoglobulins through their heavy chain (Fc region) allowing optimal orientation and antigen detection. Protein A has higher affinity for rabbit, pig, dog and cat IgG.
Price Range : 587.00 USD - 24100.00 USD

"Protein-protein Interaction Research" 1-50 of 119 Products and Services

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