PerkinElmer

Ligands

OF

Eliminate the need for antibodies and reduce assay time with direct detection using our radiolabeled ligands, which provide for sensitive and quantitative measurement of binding.

  • High specific activity — The majority of our 125I-labeled ligands are offered at maximum specific activity. This means virtually every molecule of ligand provided in the stock vial is radiolabeled. For tritiated ligands (3H ligands), pick a ligand with specific activity above 20 Ci/mmol – all of our tritiated ligands meets or exceeds these requirements.
  • High purity — We offer highly-pure radioligands for the highest specific signal with low background in binding assays.
  • High selectivity — Our broad portfolio of agonists and antagonists offers many options for choosing the most selective compound for your receptor.
  • Validated for receptor binding — all of our radioligand products are tested for receptor binding during development. Additionally, many of our radioligands are used to QC our GPCR and receptor cell lines and cell membrane products.

  • Products and Services

  • Resources, Events & More

Narrow your results
Application
  • Drug Discovery & Development (109)
  • Plant Sciences (1)
Therapeutic Area
  • Angiogenesis (4)
  • Cancer (5)
  • Cardiovascular (30)
  • CNS & Neurologic (85)
  • Diabetes (3)
  • Gastrointestinal (23)
  • Inflammation (28)
  • Metabolic Disorders (21)
  • Musculoskeletal (1)
  • Obesity (1)
  • Pain (23)
Product Brand Name
  • NEN Radiochemicals (113)
Detection Method
  • Radiometric (112)
Receptor Type
  • 5-Hydroxytryptamine (12)
  • Acetylcholine (1)
  • Acetylcholine (Muscarinic) (6)
  • Adenosine (4)
  • Adrenoceptors (8)
  • Benzodiazepine (6)
  • Bradykinin (1)
  • Calcium (4)
  • Cannabinoid (2)
  • Cholecystokinin (1)
  • Dopamine (10)
  • Dopamine Transporter (2)
  • Free Fatty Acid (1)
  • GABAA (6)
  • GABAB (1)
  • Glucagon (1)
  • Glutamate (6)
  • Glycine (4)
  • hERG (2)
  • Histamine (3)
  • Melatonin (1)
  • Nicotinic (3)
  • NMDA (1)
  • Norephinephrine (1)
  • Opioid (9)
  • Oxytocin (1)
  • Potassium (1)
  • Progestin (1)
  • Retinoic Acid Receptors (1)
  • Serotonin (4)
  • SVCT1 (1)
  • SVCT2 (1)
  • Tachykinin (1)
  • Thyrotropin Releasing Hormone (1)
  • TRPC5 (1)
  • Vasopressin (1)
  • Vesicular Amine Transporters (VATs) (1)
Radioisotope
  • C-14 (6)
  • H-3 (109)
  • S-35 (1)
Radionuclide
  • 14C (5)
  • 35S (1)
  • 3H (1)
  • 3H (108)
Label Position
  • Generally Labeled (6)
  • Nominally Labeled (24)
  • Specifically Labeled (85)
  • Uniformly Labeled (1)
Concentration
  • 1 mCi/mL (3)
  • 1.0 - 10 mCi/mL (56)
  • 1.0 - 10 µCi/mL (3)
  • <1.0 mCi/mL (7)
Pipetting Arms
Volume
  • 0-50 (36)
  • 201-250 (55)

"Ligands" 1-50 of 116 Products and Services

Sort
Per Page
Adenosine 5 Triphosphate 250 µCi

Astemizole, [O-Methyl-3H]

Astemizole (Hismanal) tritiated at the O-methyl group. Atemizole is an antagonist of the histamine H1-receptor and has been shown to block hERG potassium channels.
Price Range : 771.00 USD - 8700.00 USD
Adenosine 5 Triphosphate 250 µCi

RX 821002, [6,7-3H(N)]-

RX 821002, tritiated at the 6,7 position. RX 821002 acts as an antagonist at α2-adrenoceptors.
List Price : 2560.00 USD
Adenosine 5 Triphosphate 250 µCi

Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid (AMPA), DL-α-[5-Methyl-3H]

DL-α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid (AMPA), tritiated at the 5-methyl position. AMPA acts as an agonist at the AMPA receptor.
Price Range : 623.00 USD - 4601.00 USD
Adenosine 5 Triphosphate 250 µCi

Verapamil Hydrochloride, [N-Methyl-3H]

Verapamil hydrochloride, tritiated on the N-methyl group. Verapamil acts as a calcium channel blocker (CCB).
Price Range : 748.00 USD - 3600.00 USD
Adenosine 5 Triphosphate 250 µCi

AF-DX 384, [2,3-Dipropylamino-3H]-, 250µCi (9.25MBq)

AFDX-384 (BIBN-161) radioligand tritiated at the 2,3-dipropylamino position. AFDX-384 acts as a selective antagonist of muscarinic acetylcholine receptors, with selectivity for the M2 and M4 subtypes.
List Price : 2140.00 USD
Adenosine 5 Triphosphate 250 µCi

Diltiazem, cis-(+)-[N-Methyl-3H]

cis-(+)-Diltiazem, tritiated at the N-methyl position. Diltiazem is a non-DHP calcium channel blocker.
Price Range : 1801.00 USD - 4593.00 USD
Adenosine 5 Triphosphate 250 µCi

Pirenzepine, [N-Methyl-3H]

Pirenzepine, tritiated on the N-methyl group. Pirenzepine acts as a selective antagonist of the muscarinic M1 acetylcholine receptor.
Price Range : 2134.00 USD - 5400.00 USD

Retinoic Acid, [11,12-3H]9-cis-

9-cis-retinoic acid tritiated at the 11,12 position. It is a form of vitamin A and activates retinoic acid receptors (RARs).
List Price : 3245.00 USD
Adenosine 5 Triphosphate 250 µCi

Citalopram, [N-Methyl-3H]

Citalopram, tritiated at the N-methyl group. Citalopram is a selective serotonin reuptake inhibitor (SSRI) antidpressant drug, and has been shown to block the serotonin transporter (SERT, 5-HTT).
Price Range : 1218.00 USD - 2660.00 USD
Adenosine 5 Triphosphate 250 µCi

GABAPENTIN [3H]

Tritiated gabapentin (Neurontin). Gabapentin is a medication used to treat epilepsy, and has been shown to cross membrane lipid barriers via system L-amino acid transporters and bind to voltage-gated calcium channels in the central nervous system. This product has a scheduled release for the third Monday in February and September.
List Price : 5900.00 USD
Adenosine 5 Triphosphate 250 µCi

RO 15-4513, [7,9-3H]-, 250µCi (9.25MBq)

Ro15-4513, tritiated at the 7,9 position. Ro15-4513 is a partial inverse agonist at GABAA receptors.
List Price : 2645.00 USD
Adenosine 5 Triphosphate 250 µCi

Prazosin, [7-Methoxy-3H]

Prazosin, tritiated at the 7-methoxy position. Prazosin acts as an inverse agonist at the α1-adrenergic receptor.
Price Range : 768.00 USD - 6100.00 USD
Adenosine 5 Triphosphate 250 µCi

Norepinephrine, Levo-[ring-2,5,6-3H]

Levo-Norepinephrine, tritiated on the ring group. Norepinephrine binds and activates adrenergic receptors, and is cleared by the norepinehprine transporter (NET).
Price Range : 1458.00 USD - 9300.00 USD
Adenosine 5 Triphosphate 250 µCi

Ethylcarboxamidoadenosine, 5`-N-[Adenine-2,8-3H]-, 250µCi (9.25MBq)

5'-N-Ethylcarboxamidoadenosine (NECA), tritiated at the adenine-2,8 position. 5'-N-Ethylcarboxamidoadenosine is an adenosine analog that acts as an agonist at adenosine receptors A1, A2A, and A3.
List Price : 1739.00 USD
Adenosine 5 Triphosphate 250 µCi

CP 55940, [Side Chain-2,3,4-3H(N)]

CP 55,940, tritiated on the side chain-2,3-4 position. CP 55,940 is a synthetic cannabinoid that acts as a full agonist at both cannabinoid CB1 and CB2 receptors, and can also upregulate serotonin 5-HT2A receptors.
Price Range : 736.00 USD - 6100.00 USD
Adenosine 5 Triphosphate 250 µCi

WIN 35428, [N-Methyl-3H]

WIN 35428 [(–)-2-β-Carbomethoxy-3-β-(4-fluorophenyl)tropane], tritiated on the N-methyl group. WIN 35428 acts as an antagonist at dopamine transporters (DATs).
Price Range : 775.00 USD - 5600.00 USD
Adenosine 5 Triphosphate 250 µCi

Hemicholinium-3 Diacetate Salt, [Methyl-3H]-, 250µCi (9.25MBq)

Hemicholinium-3 (HC3; hemicholine) Diacetate Salt, tritiated on the methyl group. Hemicholinium-3 blocks reuptake of choline by the high-affinity choline transporter. This product has a scheduled lot release for the second Monday in February and August.
List Price : 3542.00 USD
Adenosine 5 Triphosphate 250 µCi

5-Hydroxytryptamine Creatinine Sulfate, [1,2-3H(N)]

5-Hydroxytryptamine Creatinine Sulfate (Serotonin, 5-HT), tritiated at the 1,2 position. 5-Hydroxytryptamine is a neurotransmitter and is the endogenous ligand for serotonin receptors.
Price Range : 820.00 USD - 2216.00 USD
Adenosine 5 Triphosphate 250 µCi

Methyl-4-Phenylpyridinium Acetate, N-[Methyl-3H]-, MPP (+)

N-Methyl-4-phenylpyridinium (MPP+) acetate, tritiated on the methyl group. MPP+ is a substrate for the organic cation ion transporter (OCT), the dopamine transporter (DAT), the norepinephrine transporter (NET), and the serotonin transporter (SERT).
Price Range : 563.00 USD - 1500.00 USD
Adenosine 5 Triphosphate 250 µCi

TCP, [Piperdyl-3,4-3H(N)]

Tenocyclidine (TCP), tritiated at the piperdyl-3,4 position. TCP acts as an antagonist at N-methyl-D-aspartate receptor (NMDA receptors).
Price Range : 712.00 USD - 2950.00 USD
Adenosine 5 Triphosphate 250 µCi

Enkephalin (2-D-Alanine-5-D-Leucine), [Tyrosyl-3,5-3H(N)]-, 250µCi (9.25MBq)

DADLE, tritiated on the tyrosyl group. Peptide sequence: Tyr-D-Ala-Gly-L-Phe-D-Leu. DADLE is a synthetic enkephalin analog considered selective for the delta opioid receptor, but has been shown to bind the mu opioid receptor as well.
List Price : 2020.00 USD
Adenosine 5 Triphosphate 250 µCi

Norepinephrine, Levo-[7-3H]

Levo-Norepinephrine, tritiated at the 7 position. Norepinephrine binds and activates adrenergic receptors, and is cleared by the norepinehprine transporter (NET). This product has a scheduled lot release for the third Monday in July.
Price Range : 1315.00 USD - 10900.00 USD
Adenosine 5 Triphosphate 250 µCi

Histamine Dihydrochloride, [Ring, Methylenes-3H(N)]

Histamine dihydrochloride, tritiated on the ring and methylene groups. Histamine is an endogenous agonist of histamine receptors.
Price Range : 1188.00 USD - 3288.00 USD
Diclofenac sodium- Phenylacetic acid C14

COUMARIN, 7-ETHOXY, [3- 14C]-

50 µCi quantities of 7-ETHOXY-[3-14C]-Coumarin are available for your research.
List Price : 2137.00 USD
Adenosine 5 Triphosphate 250 µCi

Cyclopentyl-1,3-Dipropylxanthine, 8-[Dipropyl-2,3-3H(N)]

8-Cyclopentyl-1,3-dipropylxanthine (DPCPX, PD-116,948), tritiated at the dipropyl-2,3- positions. DPCPX acts as a potent and selective antagonist for the adenosine A1 receptor.
Price Range : 1430.00 USD - 3277.00 USD

QUISQUALIC ACID, [3H]

Quisqualic acid, tritiated. Quisqualic acid acts as an agonist at AMPA receptors, kainate receptors, and group 1 metabotropic glutamate receptors.
List Price : 2624.00 USD
Adenosine 5 Triphosphate 250 µCi

Rosiglitazone, DL- [3H]-

Tritiated DL-Rosiglitazone (Avandia). Rosiglitazone acts as a selective agonist at peroxisome proliferator-activated receptors (PPARs).
List Price : 1827.00 USD
Adenosine 5 Triphosphate 250 µCi

Thyrotropin Releasing Hormone, [L-histidyl-4-3H(N), L-propyl-3,4-3H(N)]

Thyrotropin-releasing hormone (TRH), tritiated on the histidyl and propyl groups. TRH binds and activates thyrotropin-releasing hormone receptors (TRH-Rs).
Price Range : 1806.00 USD - 6600.00 USD
Adenosine 5 Triphosphate 250 µCi

SR141716A, [3H]

Tritiated SR141716A (rimonabant; Acomplia; Zimulti). SR141716A acts as an inverse agonist at the cannabinoid CB1 receptor.
List Price : 2729.00 USD
Adenosine 5 Triphosphate 250 µCi

Acetylcholine Iodide, [acetyl-3H], 1mCi (37MBq)

Acetylcholine (Ach) radioligand tritiated on the acetyl group. Acetylcholine is a neurotransmitter and the endogeous ligand that binds to and activates muscarinic and nicotinic acetylcholine receptors.
List Price : 1552.00 USD
Adenosine 5 Triphosphate 250 µCi

4-DAMP, [N-Methyl-3H]-, 250µCi (9.25MBq)

4-DAMP (1,1-dimethyl-4-diphenylacetoxypiperidinium iodide) tritiated at the N-methyl position. 4-DAMP is a selective muscarinic acetylcholinenergic receptor M3 antagonist.
List Price : 3615.00 USD
Adenosine 5 Triphosphate 250 µCi

Vinblastine Sulphate, [G-3H]

Vinblastine sulphate, tritiated. Vinblastine binds to tubulin and inhibits microtubule formation.
List Price : 1683.00 USD
Adenosine 5 Triphosphate 250 µCi

Muscimol, 3-Hydroxy-5-Aminomethylisoxazole, [Methylene-3H(N)]

3H Muscimol radioligand. Muscimol acts as a potent selective agonist at GABAA receptors. It also acts as a partial agonist at GABAA-rho receptors. This product has a scheduled lot release for the second Monday in February and August. NOTE: NET574001MC will be obsolete soon.
List Price : 1927.00 USD
Adenosine 5 Triphosphate 250 µCi

Vasopressin (8-L-Arginine), [Phenylalanyl-3,4,5-3H(N)]

Vasopressin, tritiated on the phenylalanine residue. Vasopressin binds and activates vasopressin receptors.
Price Range : 726.00 USD - 2605.00 USD
Adenosine 5 Triphosphate 250 µCi

DTG (1,3-Di-o-tolylguanidine, [p-ring-3H]-), [5-3H(N)]

DTG (Ditolylguanidine), tritiated on the p-ring and at the 5- position. DTG is a selective sigma receptor (σ-receptor) agonist.
Price Range : 2388.00 USD - 6100.00 USD
Adenosine 5 Triphosphate 250 µCi

Quinuclidinyl Benzilate, L-[Benzilic-4,4`-3H]-, 250µCi (9.25MBq)

L-quinuclidinyl benzilate (QNB), tritiated at the benzilic-4,4' position. L-quinuclidinyl benzilate acts as an antagonist at muscarinic acetylcholine receptors.
List Price : 1536.00 USD
Adenosine 5 Triphosphate 250 µCi

PK 11195, [N-Methyl-3H]

PK-11195, tritiated on the N-methyl group. PK-11195 binds selectively to the peripheral benzodiazepine receptor (PBR).
Price Range : 2200.00 USD - 4926.00 USD
Adenosine 5 Triphosphate 250 µCi

DAMGO, [Tyrosyl-3,5-3H(N)]

DAMGO, tritiated at the tyrosyl 3,5 poisition. DAMGO is a synthetic opioid analog with high specificity for the μ-opioid receptor.
Price Range : 1892.00 USD - 4893.00 USD
Adenosine 5 Triphosphate 250 µCi

SB-269970, [3H]

Tritiated SB-269970. SB-269970 is believed to act as a selective serotonin 5-HT7 antagonist, or possibly an inverse agonist.
List Price : 4240.00 USD
Adenosine 5 Triphosphate 250 µCi

Substance-P (9-Sar, 11-Met(O2)), [2-Prolyl-3,4-3H]-, 50µCi (1.85MBq)

Substance-P, tritiated on the 2-prolyl group. Substance-P acts as an antagonist at neurokinin-1 receptors (NK1Rs).
List Price : 2761.00 USD
Adenosine 5 Triphosphate 250 µCi

Norepinephrine Hydrochloride, DL-[7-3H(N)]-, 250µCi (9.25MBq)

DL-Norepinephrine hydrochloride, tritiated at the 7 position. Norepinephrine binds and activates adrenergic receptors, and is cleared by the norepinehprine transporter (NET).
List Price : 1260.00 USD

GR113808,[N-methyl-3H]-

GR113808, tritiated on the N-methyl group. GR113808 acts as a selective antagonist at the 5-HT4 receptor.
List Price : 4477.00 USD
Adenosine 5 Triphosphate 250 µCi

Lysergic Acid Diethylamide, [N-Methyl-3H]-, 250µCi (9.25MBq)

Lysergic Acid Diethylamide (LSD), tritiated on the N-methyl group. LSD is a partial agonist of dopamine D2 receptors. It also binds most serotonin receptors (5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT5B and 5-HT6). This product has a scheduled lot release for the second Monday in April, August and December.
List Price : 2167.00 USD
Adenosine 5 Triphosphate 250 µCi

Methylspiperone, [N-Methyl-3H]-, 250µCi (9.25MBq)

Methylspiperone radioligand tritiated at the N-Methyl position. Methylspiperone is an antagonist at the 5-HT2A receptor and a selective dopamine D2 antagonist.
List Price : 2593.00 USD
Adenosine 5 Triphosphate 250 µCi

5-Hydroxy tryptamine, [3H]

5-hydroxytryptamine (5-HT, or serotonin) labeled with tritium. It is a naturally occurring neurotransmitter which is tied to positive mood, certain involuntary muscle control, and countless other functions.
List Price : 799.00 USD
Adenosine 5 Triphosphate 250 µCi

Dihydroxyphenylethylamine (Dopamine), 3,4-[Ring-2,5,6-3H]

Dihydroxyphenylethylamine (dopamine, DA), tritiated at the ring-2,5,6- position. Dihydroxyphenylethylamine is a neurotransmitter and is the primary endogenous ligand for dopamine receptors.
Price Range : 704.00 USD - 1708.00 USD
Adenosine 5 Triphosphate 250 µCi

Bradykinin, [2,3-Prolyl-3,4-3H(N)]

Bradykinin, tritiated at the 2,3-prolyl-3,4 position. Bradykinin is the endogenous ligand that activates bradykinin B1 and B2 receptors.
Price Range : 1935.00 USD - 4417.00 USD
Adenosine 5 Triphosphate 250 µCi

Raclopride, [Methoxy-3H]

Raclopride, [Methoxy-3H]- will have fresh lot dates on the second Monday in March and September.
Price Range : 614.00 USD - 4903.00 USD
Adenosine 5 Triphosphate 250 µCi

Paroxetine, [Phenyl-6'-3H]

Paroxetine (Paxil), tritiated at the phenyl-6' position. Paroxetine is a selective serotonin reuptake inhibitor (SSRI). This product has a scheduled lot release for the first Monday in May and November.
Price Range : 682.00 USD - 3867.00 USD
Adenosine 5 Triphosphate 250 µCi

Scopolamine Methyl Chloride, [N-methyl-3H]

Scopolamine methyl chloride, tritiated on the N-methyl group. Scopolamine acts as an antagonist at muscarinic acetylcholine receptors.
Price Range : 1663.00 USD - 3814.00 USD

"Ligands" 1-50 of 116 Products and Services

Per Page