PerkinElmer

Lead Optimization

OF

Engineer drug candidates with the lowest risk of failure in the critical latter stages of drug development. Our lead optimization solutions reduce off-target activity through improved selectivity, enhance potency, and improve the chemical and metabolic properties of the lead compound for better in vivo pharmacodynamics and pharmacokinetics. We also offer informatics software applications that help you manage chemical structures and their associated data and properties in an efficient and chemically intelligent way.

Products & Services (140)
Filters:
Product Type
  • Accessories (43)
  • Consumables (4)
  • Instruments (11)
  • Reagents (75)
  • Software and Informatics (7)
Target Species
  • Mouse (6)
  • Rabbit (6)
Application
  • Flow Cytometry (25)
  • High Content Screening (27)
  • Imaging Microscopy (25)
  • Mobility Shift (36)
Therapeutic Area
  • Cardiovascular Diseases (8)
  • Fibrosis (3)
  • Metabolic Disorders (5)
  • Neurology (7)
  • Oncology (7)
Product Brand Name
  • EnSight (1)
  • EnVision (1)
  • FMT (1)
  • IVIS (6)
  • LabChip EZ Reader (49)
  • Operetta (28)
  • Operetta CLS (9)
  • Operetta CLS AND Opera Phenix (9)
  • PerkinElmer Signals Lead Discovery (1)
  • PhenoVue (27)
  • Victor (1)
Detection Method
  • Absorbance (3)
  • Alpha (2)
  • Fluorescence (31)
  • Fluorescence Polarization (2)
  • Image-based Cytometry (1)
  • Luminescence (3)
  • Time-Resolved Fluorescence (TRF) (3)
  • Transmission (1)
Sample Type
  • Enzyme (38)
Fluorophore
  • PhenoVue Fluor 488 (4)
  • PhenoVue Fluor 568 (4)
  • PhenoVue Fluor 594 (4)
  • PhenoVue Fluor 488 (1)
  • PhenoVue Fluor 568 (1)
  • PhenoVue Fluor 594 (1)
Automation Compatible
  • Yes (30)
Format
  • Dessicated (6)
  • Liquid (3)
  • Lyophilized (15)
  • Powder (1)
Imaging Modality
  • High Content (1)
  • microCT Imaging (1)
  • Optical Imaging (7)
Length
  • 51-100 (1)
Model Compatible With
  • Opera Phenix Plus (1)
  • Operetta (29)
  • Operetta CLS (8)
  • Operetta CLS AND Opera Phenix (10)

Sort by

1-25 of 140 Products & Services

  • IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

    IVIS® Lumina III In Vivo Imaging System

    The IVIS® Lumina Series III brings together years of leading optical imaging technologies into one easy to use and exquisitely sensitive bench-top system.
  • EnSight Multimode Plate Reader

    EnSight Multimode Plate Reader

    The EnSight multimode plate reader offers HTS Alpha, Ultra-sensitive Luminescence and fast well-imaging technologies alongside conventional multimode detection technologies. Imaging & online data analysis is fast: a 384-well plate can be imaged in less than 5 mins. The system’s modular design, combined with workflow-based Kaleido data acquisition & analysis software, gives a truly versatile plate reader that gets users productive quickly.
  • EnVision 2105 multimode plate reader

    EnVision Multimode Plate Reader

    The EnVision® 2105 multimode plate reader provides exceptional speed, ultra-high throughput, and maximum sensitivity across all detection technologies. Tried and tested, the EnVision microplate reader gives you robust performance and reliable data for high throughput screening, time after time.

    The EnVision 2105 model delivers even higher sensitivity for time-resolved fluorescence (TRF) applications, and the Enhanced Security software option includes tools to facilitate 21 CFR Part 11 compliance for integration into regulated environments (GxP).

  • IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

    IVIS® Lumina LT In Vivo Imaging System

    The IVIS® Lumina LT Series III pre-clinical in vivo imaging system offers the industries most sensitive benchtop platform at an entry level price.
  • Operetta CLS High-Content Analysis System

    Operetta CLS High-Content Analysis System

    Uncover deep biological understanding in your everyday assays and innovative applications using the Operetta CLS high-content analysis system. Featuring a unique combination of technologies, the system delivers all the speed, sensitivity and resolution you need to reveal fine sub-cellular details. And with our simple, powerful Harmony 4.5 software, Operetta CLS lets you find even subtle phenotypic changes.
  • IVIS Lumina XRMS 2D Optical Imaging System with Integrated X-ray

    IVIS Lumina XRMS In Vivo Imaging System

    Industry leading Fluorescence, Bioluminescence and X-Ray Imaging - All-In-One benchtop instrument! The IVIS® Lumina XRMS (x-ray multi-species optical imaging system) adds to the versatility of the IVIS Lumina XR by offering the flexibility to image large animals up to 500 grams with precise optical and X-Ray overlay.
  • SpectrumBL-CU-Hero

    IVIS® SpectrumBL High-Throughput In Vivo Optical Imaging System

    The IVIS® SpectrumBL is an advanced high-throughput 2D and 3D optical imaging system designed to improve quantitative outcomes of bioluminescent, chemiluminescent and Cerenkov in vivo imaging.
  • Spectrum-CU-Hero

    IVIS Spectrum In Vivo Imaging System

    The IVIS® Spectrum in vivo imaging system combines 2D optical and 3D optical tomography in one platform. The system uses leading optical technology for preclinical imaging research and development ideal for non-invasive longitudinal monitoring of disease progression, cell trafficking and gene expression patterns in living animals.
  • FMT In Vivo Imaging Instrument

    FMT 1000 In Vivo Imaging System

    The FMT® 1000 is an entry level 3D fluorescence tomographic system with the ability to quantitate a single fluorophore at a time.
  • VictorX_ImageA_320px

    VICTOR Multilabel Plate Reader

    The VICTOR Multilabel plate reader has been replaced by the VICTOR Nivo multimode plate reader. Please contact your local representative for further information, or visit the VICTOR Nivo product page (Part Number - HH35000500).
  • IVIS-SpectrumCT-Hero

    IVIS® SpectrumCT In Vivo Imaging System

    The IVIS® SpectrumCT preclinical in vivo imaging system expands upon the versatility of the IVIS Spectrum by offering 2D and 3D imaging capabilities but includes integrated low-dose microCT ideal for longitudinal studies. The system provides researchers with greater insights into complex biological systems by enabling simultaneous molecular and anatomical non-invasive imaging in animal models.
  • PerkinElmer

    ProfilerPro Kinase Peptide Substrate 6, for LabChip EZ Reader

    Fluorescently-labelled peptide substrate 6 for kinase assays (inhibiton, target discovery, lead optimization)
    List Price : 779.00 USD
  • PerkinElmer

    ProfilerPro Kinase Peptide Substrate 5, for LabChip EZ Reader

    Fluorescently-labelled peptide substrate 5 for kinase assays (inhibiton, target discovery, lead optimization)
    List Price : 780.00 USD
  • PhenoVue Fluor 488 - Goat Anti-Mouse Antibody Highly Cross-Adsorbed

    PhenoVue Fluor 488 - Goat Anti-Mouse Antibody Highly Cross-Adsorbed

    Highly cross-adsorbed goat anti-mouse IgG (H+L) antibody conjugated with PhenoVue Fluor 488.

    PhenoVue Fluor 488 secondary antibody conjugates exhibit bright green fluorescence and are validated for use in high-content screening applications.

    Part of PerkinElmer’s portfolio of cellular imaging reagents, the PhenoVue Fluor - 488 goat anti-mouse antibody, highly cross-adsorbed, has a maximum excitation wavelength of 495nm and a maximum emission wavelength of 520nm.

    List Price : 215.00 USD
  • PerkinElmer

    ProfilerPro Kinase Peptide Substrate 11, for LabChip EZ Reader

    Fluorescently-labelled peptide substrate 11 for kinase assays (inhibiton, target discovery, lead optimization)
    List Price : 780.00 USD
  • PhenoVue Fluor 488 - WGA

    PhenoVue Fluor 488 - WGA

    PhenoVue Fluor 488 - WGA is a fluorescent lectin which displays high affinity for sialic acid and N-acetylglucosamine residues of glycoproteins and glycolipids present at the cellular plasma membranes. It can be used for cellular membrane staining, particularly the Golgi apparatus.

    PhenoVue Fluor 488 - WGA exhibits bright green fluorescence and is validated for use in imaging microscopy and high-content screening applications.

    Part of PerkinElmer's portfolio of cellular imaging reagents, PhenoVue Fluor 488 - WGA has a maximum excitation wavelength of 495 nm and a maximum emission wavelength of 520 nm.

    List Price : 320.00 USD
  • PhenoVue Fluor 568 - Phalloidin

    PhenoVue Fluor 568 - Phalloidin

    PhenoVue Fluor 568 - Phalloidin is a fluorescent dye conjugated bicyclic peptide which binds specifically to F-actin and stains the actin cytoskeleton.

    PhenoVue Fluor 568 conjugated Phalloidin exhibits bright red orange fluorescence and is validated for use in imaging microscopy and high-content screening applications.

    Part of PerkinElmer's portfolio of cellular imaging reagents, PhenoVue 568 - Phalloidin has a maximum excitation wavelength of 578 nm and a maximum emission wavelength of 603 nm.

    List Price : 430.00 USD
  • PhenoVue 551 Mitochondrial Stain

    PhenoVue 551 Mitochondrial Stain

    PhenoVue 551 Mitochondrial stain is a fluorescent dye which accumulates in heathly mitochondria of live cells.

    PhenoVue 551 Mitochondrial stain exhibits bright orange fluorescence and is validated for use in imaging microscopy and high-content screening applications.

    Part of PerkinElmer's portfolio of cellular imaging reagents, PhenoVue 551 Mitochondrial stain has a maximum excitation wavelength of 551 nm and a maximum emission wavelength of 576 nm, which makes it an alternative to the similar stain MitoTracker Orange CMTMRos.

    List Price : 340.00 USD
  • PerkinElmer

    ProfilerPro Kinase Peptide Substrate 22, for LabChip EZ Reader

    Fluorescently-labelled peptide substrate 22 for kinase assays (inhibiton, target discovery, lead optimization)
    List Price : 780.00 USD
  • PerkinElmer

    ProfilerPro Kinase Selectivity Assay Plate Kit 6, for LabChip EZ Reader

    Kit consist of matched pairs of 384-well kinase-assay and substrate plates. Each assay plate contains 24 different predispensed frozen kinases. Substrate plates contain the appropriate fluorescent labeled peptides and ATP.
    List Price : 1686.00 USD
  • PerkinElmer

    ProfilerPro Kinase Peptide Substrate 29, for LabChip EZ Reader

    Fluorescently-labelled peptide substrate 29 for kinase assays (inhibiton, target discovery, lead optimization)
    List Price : 780.00 USD
  • PerkinElmer

    ProfilerPro Kinase Peptide Substrate 14, for LabChip EZ Reader

    Fluorescently-labelled peptide substrate 14 for kinase assays (inhibiton, target discovery, lead optimization)
    List Price : 780.00 USD
  • PhenoVue Fluor 568 - Goat Anti-Mouse Antibody Cross-Adsorbed

    PhenoVue Fluor 568 - Goat Anti-Mouse Antibody Cross-Adsorbed

    Cross-Adsorbed goat anti-mouse IgG (H+L) antibody conjugated with PhenoVue Fluor 568.

    PhenoVue Fluor 568 secondary antibody conjugates exhibit bright red-orange fluorescence and are validated for use in high-content screening applications.

    Part of PerkinElmer’s portfolio of cellular imaging reagents, the PhenoVue Fluor - 568 goat anti-mouse antibody, cross-adsorbed, has a maximum excitation wavelength of 578nm and a maximum emission wavelength of 603nm.

    List Price : 175.00 USD
  • PerkinElmer

    ProfilerPro Kinase Peptide Substrate 2, for LabChip EZ Reader

    Fluorescently-labelled peptide substrate 2 for kinase assays (inhibiton, target discovery, lead optimization)
    List Price : 780.00 USD
  • PerkinElmer

    ProfilerPro Kinase Selectivity Assay Plate Kit 4, for LabChip EZ Reader

    Kit consist of matched pairs of 384-well kinase-assay and substrate plates. Each assay plate contains 24 different predispensed frozen kinases. Substrate plates contain the appropriate fluorescent labeled peptides and ATP.
    List Price : 1686.00 USD
  • Jump to:
Resource Library (312)
Filters:
Resource Library
  • Application Note (13)
  • Article (4)
  • Brochure (1)
  • Case Study (3)
  • Ebook (3)
  • Poster (3)
  • Technical Note (7)
  • White Paper (4)
Events

Sort by

1-25 of 38 Resource Library

  • Jump to: