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The AlphaLISA® SureFire® Ultra™ p-Ribosomal Protein S6 (Ser235/236) assay is a sandwich immunoassay for quantitative detection of phospho- Ribosomal Protein S6 (phosphorylated on Ser3235/236) in cellular lysates using Alpha Technology.
Label and track mammalian cells including stem cells, T-cells, macrophages and more with VivoTrack™ fluorescent labeling dye.
VivoTrack 680 is an NIR fluorescent lipophilic dye that intercalates in the cell membrane. With high solubility and excellent stability, VivoTrack offers superior brightness and uniform labeling, ideal for cell detection in vitro and longitudinal cell tracking in vivo across many applications including inflammation, immunology, and stem cell research.
The AlphaLISA® SureFire® Ultra™ Multiplex phospho-STAT1 (Tyr701) + Total STAT1 assay kit is used to measure both the phosphorylation of STAT1 and total levels of endogenous STAT1 in cellular lysates. The assay is an ideal system for the screening of modulators of receptor activation (e.g. agonists and antagonists) as well as agents acting intracellularly, such as small molecule inhibitors of signal transduction. The assay will measure STAT1 phosphorylation by either recombinant or endogenous receptors and can be applied to primary cells.
In vivo optical imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. In oncology, increases in tumor vascular permeability can be an early indicator of tumor angiogenesis. In inflammatory disease increased vascular permeability can indicate alterations in fluid homeostasis in an acute edema response or in chronic organ conditions.
PerkinElmer’s AngioSense® NIR fluorescent probes are designed to evaluate vascular changes to better understand various disease states or provide valuable information on effects of drug candidates earlier in the development process.
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