PerkinElmer

Reagents for GPCR Research

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GPCR research remains a widely studied area in drug discovery. As the complexity of the roles of GPCRs in signaling are unraveled, it is as important as ever to have reagents you can trust. We offer just that, with assay reagents for any GPCR target, including Gs-, Gq- and Gi-coupled receptors. Whether you are looking for functional or binding assays, our portfolio is sure to offer what you need.

Our GPCR research reagents portfolio offers solutions for identifying and monitoring a variety of GPCR research applications, including:

  • GPCR pathway activation via intracellular calcium, cAMP, phospho-ERK, inositol phosphates
  • Reporter gene expression in response to GPCR signaling
  • Receptor-ligand binding
  • GTPγS binding activity

Receptor Cell Lines & Membranes

Our selection of GPCR cell lines and membranes allows you to decrease your assay development time and increase the quality of your results. Our cell lines and membrane preparation are validated for optimal performance in both function and binding assays.

See our full selection of receptor cell lines and membranes here

Radiolabeled Ligands

Receptor binding studies are an integral part of GPCR research. Our radioligand are all tested specifically for receptor binding during development. Furthermore, many of our GPCR related radioligands are used to QC our GPCR cell lines and membrane preparations.

For research and investigational use only.

See our full selection of radiolabeled ligands here

See our full selection on iodinated compounds here

HTRF

 

 

A wide selection of HTRF® kits are available to address the whole GPCR activation pathway in a sensitive, homogeneous assay format. The range of over 120 products includes ligand binding with the Tag-Lite platform, 2nd messenger studies with cAMP Gs/Gi and IP-One Gq kits, and downstream GPCR signaling with phosphorylation assays.

Suggested Content

Visit the full range for GPCRs Discover Beta-arrestin recruitment kit Learn more on GTP Gi Binding assay Explore Gq signaling

LANCE cAMP

 

PerkinElmer's innovative LANCE® cAMP assay combines homogeneous TR-FRET technology with red-shifted Alexa® Fluor dye chemistry for maximum excitation/emission discrimination. The result is a FRET assay without the compound interference associated with blue dyes. You can read longer without accumulating background signal to maximize S/N and Z'.

AlphaLISA SureFire Ultra

This assay platform for the detection of phosphoproteins in simple to complex matrices serves as an excellent secondary technology for challenging targets and provides an alternative for tough-to-screen targets not optimally coupled through the calcium or cAMP pathway
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