PerkinElmer

AlphaLISA Binding Kits

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The interactions and binding of proteins are implicated in a large number of biological processes. The need for an efficient, highly sensitive assay to study large protein interactions is increasingly important. Alpha Technology is a highly flexible, homogeneous, no-wash assay ideal for the measurement of protein interactions and complexes as large as 200 nm in size. A bead-based proximity assay, Alpha Technology offers the possibility to assay many biological targets, including enzymes, receptor-ligand interactions, low affinity interactions, second messenger levels, DNA, RNA, proteins, peptides, sugars and small molecules.

Features:

  • No-wash steps, no separation steps
  • Ease-of-use: few addition steps, fast assay development
  • Broad range of affinities: detect strong or weak interactions, from pM to mM affinity
  • Distance: measure very large protein or antibody complexes – spanning up to 200 nm or more
  • High avidity: multiple binding sites on each bead enables use of nanomolar concentrations of antibodies or proteins, as well as use of low affinity binders

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Application
  • Protein Analysis & Detection (1)
  • Protein-protein interactions (8)
Assay points(200-50,000)
  • 100 (4)
  • 500 (9)
  • 5000 (9)
Assay Target
  • CD80 (1)
  • CD86 (1)
  • CTLA4 (2)
  • EGF (1)
  • EGFR (1)
  • FCGR3A (2)
  • HLA-DRA (1)
  • LAG3 (1)
  • PD-1 (1)
  • PD-L1 (1)
  • PDGF-BB (2)
  • PDGFR (2)
Assay Target Class
  • Fc-receptor (2)
  • Protein (7)
Experimental Type
  • In vitro (4)
Format
  • Microplates (4)
Therapeutic Area
  • Biologics/Bioprocess (2)
  • Cancer (7)

"AlphaLISA Binding Kits" 1-9 of 9 Products and Services

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AlphaLISA binding assay

PDGF-BB/PDGFRβ (human) AlphaLISA Binding Kit

This kit is designed for the detection of binding activity between Human PDGF-BB and PDGFRβ, using a homogeneous AlphaLISA assay (no wash step). This assay can facilitate the design and development of antibody therapeutics by using competitive binding to PDGF-BB and PDGFRβ.
Price Range : 1747.00 USD - 14000.00 USD
AlphaLISA binding assay

PDGF-BB/PDGFRα (human) AlphaLISA Binding Kit

This kit is designed for the detection of binding activity between Human PDGF-BB and PDGFRα, using a homogeneous AlphaLISA assay (no wash step). This assay can facilitate the design and development of antibody therapeutics by using competitive binding to PDGF-BB and PDGFRα.
Price Range : 1747.00 USD - 14000.00 USD
AlphaLISA binding assay principle

PD-1/PD-L1 (human) AlphaLISA Binding Kit

The AlphaLISA® PD-1/PD-L1 Binding Kit is designed for the detection of binding activity between Human PD-1 and PD-L1, using a homogeneous AlphaLISA assay (no wash steps). This assay can facilitate the design and development of therapeutics which competitively inhibit PD-1/PD-L1 interaction.
Price Range : 675.00 USD - 9500.00 USD
AlphaLISA binding assay

HLA-DRA/LAG3 (human) AlphaLISA Binding Kit

This kit is designed for the detection of binding activity between Human HLA-DRA and LAG3, using a homogeneous AlphaLISA assay (no wash step). This assay can facilitate the design and development of antibody therapeutics by using competitive binding to HLA-DRA and LAG3.
Price Range : 1747.00 USD - 14000.00 USD
Assay principle for LANCE TR-FRET binding assay

CTLA4-CD80 AlphaLISA Binding Kit

This kit is designed for the detection of binding activity between Human CTLA-4 and CD80, using a homogeneous AlphaLISA assay (no wash steps). This assay can facilitate the design and development of antibody therapetics by using competitive binding to CTLA-4/CD80.
Price Range : 1747.00 USD - 10600.00 USD
Alpha binding assay principle

EGF/EGFR AlphaLISA Binding Kit

The AlphaLISA® EGF/EGFR Binding Kit is designed for the detection of binding activity between Human EGF and EGFR, using a homogeneous AlphaLISA assay (no wash steps). This assay can facilitate the design and development of therapeutics which competitively inhibit the EGF/EGFR interaction.
Price Range : 675.00 USD - 9500.00 USD
PerkinElmer

FCGR3A/CD16A (176Phe/F158) (human) AlphaLISA Detection Kit

This kit is designed for the detection of binding activity between human FCGR3A (176Phe) and human IgG Fc fragment using a homogeneous AlphaLISA® assay (no wash steps). This assay can facilitate the design and development of antibody therapetics by using competitive binding.
Price Range : 566.00 USD - 10300.00 USD
Alpha Fc receptor bind

FCGR3A/CD16a (176Val/V158) AlphaLISA Binding Kit

This kit is designed for the detection of binding activity between human FCGR3A (176Val) and human IgG Fc fragment using a homogeneous AlphaLISA® assay (no wash steps). This assay can facilitate the design and development of antibody therapetics by using competitive binding.
Price Range : 675.00 USD - 10300.00 USD
Assay principle for LANCE TR-FRET binding assay

CTLA4-CD86 AlphaLISA Binding Kit

This kit is designed for the detection of binding activity between Human CTLA-4 and CD86, using a homogeneous AlphaLISA assay (no wash steps). This assay can facilitate the design and development of antibody therapetics by using competitive binding to CTLA-4/CD86.
Price Range : 1747.00 USD - 10600.00 USD

"AlphaLISA Binding Kits" 1-9 of 9 Products and Services