PerkinElmer

QA/QC Drug Manufacturing Process

Business Insights (38)
Filters:

Filters :

Resource Library
  • Application Note (31)
  • Flyer (2)
  • Guide (1)
  • Poster (3)
  • White Paper (1)

1-12 of 38 Business Insights

Sort by

  • Guide

    Safeguarding the Authenticity of Herbs & Spices

    Infrared (IR) and near-infrared (NIR) spectroscopy are fast, easy-to-use techniques with a history of being used for food applications such as those for measuring protein, moisture, and fat content. Food fraud and adulteration has become of particular concern to the industry over the past few years following reports of incidents in the media, with herbs and spices identified as one of the key problem areas.

  • White Paper

    Streamlining Materials Innovation Processes with Electronic Lab Notebook (ELN) and Data Analytics for Optimum Efficiency

    This paper explores the numerous challenges materials scientists and engineers face, from the time it takes to bring new materials to market to the difficulties delivering suitable formulations and testing against specified criteria, and how those can be resolved.

  • Application Note

    Trace Metals in Waters by GFAAS, in Accordance with U.S. EPA and Health Canada Requirements

    Precise and accurate measurements at the regulated levels are an important factor for assuring safe drinking water. U.S. EPA Method 200.91 is the method cited by EPA, Health Canada, and the WHO for the use of graphite furnace atomic absorption spectroscopy (GFAAS). In evaluating a GFAAS system for determination of these elements, it must provide good sensitivity, low noise, limited drift, and accuracy in matrices with high salt content (hard water) that might be found in drinking waters. In this work, the PinAAcle™ 900T, with a unique optical system, is evaluated for the use of EPA Method 200.9 for As, Cd, Pb, Se, and Tl in drinking waters.

  • Application Note

    Fast Digestion Analysis of Lead and Cadmium in Rice Using GFAAS with Deuterium Background Correction

    Toxic elements, such as lead (Pb) and cadmium (Cd), are entering the food chain through environmental contamination. Rice, as the most widely consumed cereal grain in Asia, can quickly pick up Pb and Cd from soil, thereby seriously endangering human health through diet. These toxic element levels need to be carefully monitored. Maximum levels of Pb and Cd are strictly regulated in Asian countries, especially in China; therefore, it is extremely important to develop a simple, reliable method for trace levels of Pb and Cd in rice. The allowable maximum levels of Pb and Cd in grains in EU and China are required to be below 0.2 mg/kg (Commission Regulation EC 1881/2006 and Chinese GB 2715-2016 Hygienic Standard). Graphite furnace atomic absorption spectroscopy (GFAAS) is the officially recommended technique for detection of trace elements in various food stuffs (GB/T 5009.15-2017, GB/T 5009. 12-2017 and EN 14083:2003). Food samples are usually pretreated before GFAAS analysis using various methods: microwave digestion, hot block digestion, dry ashing, and hot plate digestion. These conventional digestion procedures are usually complicated and time-consuming (2-4 hours or longer). Plus, they require large quantities of corrosive and oxidizing reagents, increasing the chance for contamination which could lead to inaccurate results. However, fast digestion can effectively speed up the sample preparation procedure while reducing the use of corrosive reagents and the chance for contamination.

  • Application Note

    Accurate Sizing and Precise Counting of 10 nm Gold Nanoparticles using the NexION 2000 ICP-MS

    In this work, we demonstrate that PerkinElmer's NexION® 2000 ICP-MS, with its unique RF generator and ion optics, coupled with the Syngistix™ Nano Application Software Module, can be used to accurately measure and characterize NP sizes of 10 nm and smaller, both alone and in a mixture of NPs of various sizes.

  • Application Note

    Vascular Imaging Probes For Oncology and Inflammation Using the IVIS Spectrum

    Optical-based in vivo imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. A number of fluorescent imaging probes that circulate with the blood, but have no target selectivity, have been used to detect tumor leakiness as an indication of abnormal tumor vasculature. Inflammation is also characterized by distinct vascular changes, including vasodilation and increased vascular permeability, which are induced by the actions of various inflammatory mediators. This process is essential for facilitating access for appropriate cells, cytokines, and other factors to tissue sites in need of healing or protection from infection. This application note investigates the use of three fluorescent imaging probes, to detect and monitor vascular leak and inflammation in preclinical mouse breast cancer models.

  • Application Note

    Multiplex 2D Imaging of NIR Molecular Imaging Agents on the IVIS SpectrumCT and FMT 4000

    Epifluorescence (2D) imaging of superficially implanted mouse tumor xenograft models offers a fast and simple method for assessing tumor progression or response to therapy. This approach for tumor assessment requires the use of near infrared (NIR) imaging agents specific for different aspects of tumor biology, and this Application Note highlights the ease and utility of multiplex NIR fluorescence imaging to characterize the complex biology within tumors growing in a living mouse.

  • Application Note

    Distinguishing Cell Types by Phenotypic Profiling of the Nucleus

    The promise of high-content screening is the acceleration of discovery by extracting as much relevant information as possible from cells. Nevertheless, a large percentage of high-content screens analyze only a small number of image-based properties. As a result, valuable information from precious cells and disease models is not utilized. As nearly all screening approaches require a nuclear counterstain such as Hoechst to facilitate segmentation, phenotypic profiling of the nuclei can offer new and additional perspectives on assays at no extra cost.

  • Application Note

    Discrimination of Herbal Lifestyle Products Using AssureID SIMCA and COMPARE Algorithms

    Herbal lifestyle products are widely used as alternatives to medicines around the world, with as many as 80% of people using them as a primary source of healthcare in developing countries. These treatments are commonly regarded by scientific papers, and on some occasions the media, as being inferior to orthodox treatment. This is due to the variation between herbal formulations which will not be present in so called ‘single-chemical’ drugs. The reasons for the aforementioned variation involve several factors including storage, environmental conditions, handling and unintentional or intentional contamination (adulteration).

  • Application Note

    Using FIMS to Determine Mercury Content in Sewage Sludge, Sediment and Soil Samples

    In this work, samples were digested with aqua regia using reflux conditions according to DIN method 38414. After proper dilution of the digested sample solution, Hg was measured interference-free using SnCl2 as the reductant. The recoveries of spiked mercury in sewage sludge samples ranged from 96 to 100%. The method was checked by the analysis of standard reference materials. All results were in agreement with certified values. The RSD for three replicates was approximately 2% at 10 µg/L Hg level.

  • Application Note

    Imaging Hepatocellular Liver Injury using NIR-labeled Annexin V

    Drug induced liver injury (DILI) is a major reason for late stage termination of drug discovery research projects, highlighting the importance of early integration of liver safety assessment in the drug development process. A technical approach for in vivo toxicology determination was developed using Acetaminophen (APAP), a commonly used over-the-counter analgesic and antipyretic drug, to induce acute hepatocellular liver injury.

  • Application Note

    Quantification of Nanoparticle Uptake into Cancer Cells using Single Cell ICP-MS

    Nanoparticles (NPs) have been of significant interest over the last two decades as they offer attractive benefits for drug delivery to overcome limitations in conventional chemotherapy. Nanoparticles can be engineered to carry both drugs and imaging probes to simultaneously detect and treat cancer. They may also be designed to specifically target diseased tissues and cells in the body. A number of nanoparticlebased cancer therapeutics have been approved for clinical use and/or are currently under development.

  • Jump to:
Products & Services (88)
Filters:

Filters :

Product Type
  • Accessories (38)
  • Consumables (20)
  • Instruments (19)
  • Reagents (3)
  • Software and Informatics (8)
Application
  • DNA/RNA Quantitation and QC (1)
  • Protein Analysis (1)
Product Brand Name
  • ATPlite 3D (2)
  • DELFIA (1)
  • DropletQuant / LabChip DS (1)
  • EnSight (1)
  • EnSpire (2)
  • EnVision (2)
  • FIAS (1)
  • FIMS (1)
  • IVIS (6)
  • NexION (2)
  • Opera Phenix (1)
  • Operetta (29)
  • Operetta CLS AND Opera Phenix (7)
  • PinAAcle (3)
  • Quantum (1)
  • Spectrum Two N (1)
  • Titan (1)
  • Victor (1)
Detection Method
  • Absorbance (3)
  • Alpha (2)
  • DELFIA TRF (1)
  • Fluorescence (4)
  • Fluorescence Polarization (2)
  • Image-based Cytometry (1)
  • Luminescence (5)
  • Time-Resolved Fluorescence (TRF) (4)
  • Transmission (1)
Sample Type
  • Protein (1)
Volume Capacity
  • 125 mL (16)
Grade
  • Pure Plus (2)
Assay Points (200-50,000)
  • 300 (1)
Automation Compatible
  • Yes (6)
Concentration
  • 1 µg/mL (1)
  • 100 µg/mL (2)
  • 1100 µg/mL (1)
  • 200 µg/mL (1)
  • 50 µg/mL (1)
Depth
  • 30.0 cm (1)
  • 41.0 cm (2)
  • 63.5 cm (1)
  • 69.0 cm (2)
Experimental Type
  • In vitro (1)
Format
  • Microplates (1)
Imaging Modality
  • High Content (1)
  • microCT Imaging (2)
  • Optical Imaging (6)
Length
  • 101-200 (1)
Maximum Temperature (Celsius)
  • 40-50 (2)
  • 50-60 (2)
Model Compatible With
  • Operetta (30)
  • Operetta CLS AND Opera Phenix (8)
Number of Elements
  • Multiple (8)
  • Single (1)
Product Group
  • Inorganic (2)
  • Instrument (1)
  • Software and Informatics (3)
Standard Type
  • USP/ICH Standards (17)
Technology
  • Atomic Absorption (3)
  • ICP Mass Spectrometry (1)
  • Infrared (IR) (1)
  • Mercury Analysis Systems (2)
Technology Type
  • Atomic Absorption (1)
  • ICP Mass Spectrometry (1)
  • ICP Optical Emission Spectroscopy (1)

1-12 of 88 Products & Services

Sort by

  • FIMS-400 Flow Injection Mercury Analyzer

    FIMS Flow Injection Mercury System

    The FIMS is a compact, easy-to-operate mercury analyzer with an integrated flow injection system for cold vapor mercury AA.
  • IVIS Spectrum In Vivo Imaging System

    IVIS Spectrum In Vivo Imaging System

    The IVIS® Spectrum in vivo imaging system combines 2D optical and 3D optical tomography in one platform. The system uses leading optical technology for preclinical imaging research and development ideal for non-invasive longitudinal monitoring of disease progression, cell trafficking and gene expression patterns in living animals.
  • NexION 1000B ICP-MS

    NexION 1000 ICP Mass Spectrometer

    The NexION® 1000 ICP-MS is the ideal high-throughput system for routine, multi-elemental, trace-level analyses that meet regulatory standards – and that works within your budget. It features a host of proprietary technologies that combine to deliver exceptional speed and operational simplicity, making your lab more efficient than ever before.
  • NexION 2000 ICP-MS

    NexION 2000 ICP Mass Spectrometer

    PerkinElmer’s NexION® 2000 is the most versatile ICP-MS on the market, featuring an array of unique technologies that combine to deliver the highest performance no matter what your analytical challenge. Discover the effortless versatility of an instrument that makes it easy to handle any sample matrix, any interference, and any particle size.

    PerkinElmer received on April 11, 2018 the Application Award from LaborPraxis in the category Bio and Pharma Analysis for the NexION 2000 ICP-MS. We were awarded this prize during analytica 2018 in Munich, Germany, in acknowledgment of a new technique enabling users to quantify the amount of metal in an individual cell for the first time.
  • Spectrum Two N FT-NIR Spectrometer

    Spectrum Two N FT-NIR Spectrometer

    The Spectrum Two N is a high-performance, yet robust and transportable FT-NIR system platform enabling simple, reliable NIR analyses. It’s the perfect system for labs that need to combine high-end performance with the ease-of-use features of a portable instrument, allowing users with different levels of expertise, from novice to seasoned professionals, to be proficient with it in no time.
  • IVIS Spectrum In Vivo Imaging System

    IVIS SpectrumBL High-Throughput In Vivo Optical Imaging System

    The IVIS® SpectrumBL is an advanced high-throughput 2D and 3D optical imaging system designed to improve quantitative outcomes of bioluminescent, chemiluminescent and Cerenkov in vivo imaging.
  • VictorX_ImageA_320px

    VICTOR Multilabel Plate Reader

    The VICTOR Multilabel plate reader has been replaced by the VICTOR Nivo multimode plate reader. Please contact your local representative for further information, or visit the VICTOR Nivo product page (Part Number - HH35000500).
  • 1000x1000_Opera_Phenix

    Opera Phenix High-Content Screening System

    The Opera Phenix High Content Screening System is the premier confocal solution for today's most demanding high content applications. Drawing on over a decade of experience with the industry-leading Opera® High Content Screening System, the Opera Phenix is designed for high-throughput, phenotypic screening and assays involving complex disease models, such as live cells, primary cells and microtissues.
  • IVIS Lumina XRMS 2D Optical Imaging System with Integrated X-ray

    IVIS Lumina XRMS In Vivo Imaging System

    Industry leading Fluorescence, Bioluminescence and X-Ray Imaging - All-In-One benchtop instrument! The IVIS® Lumina XRMS (x-ray multi-species optical imaging system) adds to the versatility of the IVIS Lumina XR by offering the flexibility to image large animals up to 500 grams with precise optical and X-Ray overlay.
  • PinAAcle 900T Atomic Absorption Spectrometer

    PinAAcle 900Z Atomic Absorption Spectrometer

    For laboratories needing a high-performance furnace-only atomic absorption (AA) spectrometer, the PinAAcle 900Z is a longitudinal Zeeman system with a true double-beam design for fast start-up and exceptional long-term stability.
  • FIAS-400 Flow Injection System

    FIAS Flow Injection System

    The FIAS is a fully integrated and automated flow injection mercury/hydride analysis system that provides new levels of automation and sample handling for AA, ICP and ICP-MS, dramatically increasing laboratory productivity and capability.
  • IVIS SpectrumCT 2D/3D Optical/CT In Vivo Imaging System

    IVIS SpectrumCT In Vivo Imaging System

    The IVIS® SpectumCT preclinical in vivo imaging system expands upon the versatility of the IVIS Spectrum by offering 2D and 3D imaging capabilities but includes integrated low-dose microCT ideal for longitudinal studies. The system provides researchers with greater insights into complex biological systems by enabling simultaneous molecular and anatomical non-invasive imaging in animal models.
  • Jump to: