1-12 of 38 Business Insights
Infrared (IR) and near-infrared (NIR) spectroscopy are fast, easy-to-use techniques with a history of being used for food applications such as those for measuring protein, moisture, and fat content. Food fraud and adulteration has become of particular concern to the industry over the past few years following reports of incidents in the media, with herbs and spices identified as one of the key problem areas.
This paper explores the numerous challenges materials scientists and engineers face, from the time it takes to bring new materials to market to the difficulties delivering suitable formulations and testing against specified criteria, and how those can be resolved.
In this work, we demonstrate that PerkinElmer's NexION® 2000 ICP-MS, with its unique RF generator and ion optics, coupled with the Syngistix™ Nano Application Software Module, can be used to accurately measure and characterize NP sizes of 10 nm and smaller, both alone and in a mixture of NPs of various sizes.
Toxic elements, such as lead (Pb) and cadmium (Cd), are entering the food chain through environmental contamination. Rice, as the most widely consumed cereal grain in Asia, can quickly pick up Pb and Cd from soil, thereby seriously endangering human health through diet. These toxic element levels need to be carefully monitored. Maximum levels of Pb and Cd are strictly regulated in Asian countries, especially in China; therefore, it is extremely important to develop a simple, reliable method for trace levels of Pb and Cd in rice. The allowable maximum levels of Pb and Cd in grains in EU and China are required to be below 0.2 mg/kg (Commission Regulation EC 1881/2006 and Chinese GB 2715-2016 Hygienic Standard). Graphite furnace atomic absorption spectroscopy (GFAAS) is the officially recommended technique for detection of trace elements in various food stuffs (GB/T 5009.15-2017, GB/T 5009. 12-2017 and EN 14083:2003). Food samples are usually pretreated before GFAAS analysis using various methods: microwave digestion, hot block digestion, dry ashing, and hot plate digestion. These conventional digestion procedures are usually complicated and time-consuming (2-4 hours or longer). Plus, they require large quantities of corrosive and oxidizing reagents, increasing the chance for contamination which could lead to inaccurate results. However, fast digestion can effectively speed up the sample preparation procedure while reducing the use of corrosive reagents and the chance for contamination.
Measuring the amount of metals in CNTs presents a challenge. High levels can be measured directly in the solid by several techniques, including XRF and TEM, while low-level analysis requires complete digestion of the sample prior to analysis by ICP-OES or ICP-MS.
Precise and accurate measurements at the regulated levels are an important factor for assuring safe drinking water. U.S. EPA Method 200.91 is the method cited by EPA, Health Canada, and the WHO for the use of graphite furnace atomic absorption spectroscopy (GFAAS). In evaluating a GFAAS system for determination of these elements, it must provide good sensitivity, low noise, limited drift, and accuracy in matrices with high salt content (hard water) that might be found in drinking waters. In this work, the PinAAcle™ 900T, with a unique optical system, is evaluated for the use of EPA Method 200.9 for As, Cd, Pb, Se, and Tl in drinking waters.
Through the years, both industry and analytical instrumentation have advanced. With the development of new chemicals and processes, new pollutants may enter the environment. However, the capabilities of analytical instruments have also increased, allowing the measurement of ever lower levels of environmental contaminants, as well as new pollutants.
Lead (Pb) and cadmium (Cd) are common pollutants in grains and are extremely toxic. Pb is harmful to human organs even at trace levels, and once it accumulates in the body, it causes inhibition of hemoglobin formation and neurological disorders. Cd is even classified as human carcinogen [Group 1 - according to International Agency for Research on Cancer]. It is reported that Cd leads to severe kidney problems which can be fatal and is also associated with brittle bones and liver problems. Rice, as the most widely consumed cereal grain in Asia/China, can quickly pick up Pb and Cd from toxins, pesticides and fertilizers in the soil, thereby endangering the health of millions of people through their diet. Therefore, it is extremely important to develop a simple, reliable method to monitor the levels of Pb and Cd in rice. According to Chinese national standard GB 2715-2016 Hygienic Standard for Grain, the maximum concentrations of Pb or Cd in grains must be below 0.2 mg/kg; the allowable level in the European Union is the same [EC 1881/2006]. The official technique for the determination of heavy metals in both cases is graphite furnace atomic absorption spectroscopy (GFAAS, GB/T 5009. 12-2017, GB/T 5009-2017. 15 and EN 14083:2003). Samples can be pretreated using various methods, including microwave digestion, hot block digestion, dry ashing, and hot plate digestion. It is found that these conventional digestion procedures are always complicated and time-consuming (two-four hours or even longer). Plus, conventional sample preparation techniques require large quantities of corrosive and oxidizing reagents, increasing the chance for contamination which could lead to inaccurate results. Special PTFE vessels are needed for microwave digestion; however, reusable utensils might also cause cross contamination.
Near-infrared (NIR) spectroscopy is an important technique for materials checking at various stages of the manufacturing process, but is particularly useful at the raw materials inspection stage. Raw materials come in a variety of physical forms including liquids, gels, and solids, requiring a versatile instrument with convenient, interchangeable sampling modules to cater to the entire range of raw materials encountered.
Herbal lifestyle products are widely used as alternatives to medicines around the world, with as many as 80% of people using them as a primary source of healthcare in developing countries. These treatments are commonly regarded by scientific papers, and on some occasions the media, as being inferior to orthodox treatment. This is due to the variation between herbal formulations which will not be present in so called ‘single-chemical’ drugs. The reasons for the aforementioned variation involve several factors including storage, environmental conditions, handling and unintentional or intentional contamination (adulteration).
This work has demonstrated the ability of the NexION 2000 ICP-MS to analyze both natural and drinking water samples in Standard (i.e. non-cell) mode, in accordance with U.S. EPA Method 200.8. Accuracy has been demonstrated through the analysis of several reference materials and spike recoveries, with stability of at least nine hours. Method detection limits allow for trace-level determinations, while the ability to selectively suppress user-defined isotopes also allows the measurement of analyte levels usually only possible by ICP-OES or Flame AA. The NexION 2000 provides a comprehensive solution to the challenge of U.S. EPA Method 200.8 and other drinking and natural water analytical requirements across the globe.
Extracellular signal-regulated kinase (ERK) is a key component in the regulation of embryogenesis, cell differentiation, cell proliferation, and cell death. The ERK signaling pathway is altered in various cancer types and is frequently investigated as a target for therapeutic intervention. This application note describes how a live cell FRET assay to study ERK signaling was performed on the Operetta CLS™ high-content analysis system. The optimized design of the FRET-based biosensor, the high-quality imaging of the Operetta CLS system and the easy-to-use image analysis tools of the Harmony® software contribute to the robustness of the high-content assay.
1-12 of 88 Products & Services
For laboratories needing a high-performance atomic absorption (AA) spectrometer, the PinAAcle™ 900H is a combined flame/furnace system with continuum source background correction.
Because different laboratories have different needs, we provide a full suite of powerful software tools for the PinAAcle 900H, starting with the innovative and easy-to-use Syngistix™ for AA Express, the more comprehensive Syngistix for AA standard software, or you can add on the special Syngistix Enhanced Security™ option that fulfills the special needs of highly regulated laboratories, such as those operating under the rules of 21 CFR Part 11.